Protein: PKN2
Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)

Gene: PKN2
Organism: Homo sapiens
Interactions: 176
UniProt ID: Q16513

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004697 - diacylglycerol-dependent serine/threonine kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

962091

RHOA
Transforming protein RhoA

7

20

Small-scale

0.960

High

788930

TGFR2
TGF-beta receptor type-2

3

6

High-throughput

0.861

High

1086163

CETN1
Centrin-1

3

4

High-throughput

0.855

High

1157515

PKN2
Serine/threonine-protein kinase N2

3

19

Small-scale

0.827

High

69781

ZN785
Zinc finger protein 785

2

2

High-throughput

0.811

High

1157539

CAMKV
CaM kinase-like vesicle-associated protein

2

7

High-throughput

0.811

High

1157541

HAVR2
Hepatitis A virus cellular receptor 2

2

1

High-throughput

0.811

High

193582

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

20

Small-scale

0.800

High

832902

CETN2
Centrin-2

2

4

High-throughput

0.776

High

241804

PRKN
E3 ubiquitin-protein ligase parkin

2

19

High-throughput

0.754

High

461524

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.754

High

978036

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1157525

DEFI8
Differentially expressed in FDCP 8 homolog

2

19

High-throughput

0.726

High

728264

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

Small-scale

0.713

High

1157554

ZN747
Zinc finger protein 747

2

2

High-throughput

0.694

High

298393

DNJC8
DnaJ homolog subfamily C member 8

1

4

High-throughput

0.691

High

573836

CCNB1
G2/mitotic-specific cyclin-B1

1

4

High-throughput

0.691

High

601968

ZNF8
Zinc finger protein 8

1

1

High-throughput

0.691

High

854436

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

1

High-throughput

0.691

High

1157444

PKN1
Serine/threonine-protein kinase N1

1

18

High-throughput

0.691

High

1157538

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.691

High

1157546

ZN524
Zinc finger protein 524

1

3

High-throughput

0.691

High

1157521

FRPD2
FERM and PDZ domain-containing protein 2

3

17

High-throughput

0.667

High

1130746

RRP5
Protein RRP5 homolog

1

1

High-throughput

0.665

High

295178

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

8

High-throughput

0.656

High

619065

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

3

Small-scale

0.647

High

1157564

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

20

High-throughput

0.628

High

868701

LEG7
Galectin-7

3

0

High-throughput

0.622

High

126617

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

373952

RASN
GTPase NRas

1

12

High-throughput

0.618

High

375558

RASK
GTPase KRas

1

12

High-throughput

0.618

High

466276

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

468415

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

541512

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

581072

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

830815

CCNF
Cyclin-F

1

12

High-throughput

0.618

High

845659

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.618

High

910073

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

955216

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

988396

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015464

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1105938

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

11

High-throughput

0.618

High

1140333

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.618

High

1151708

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1152511

ELAV1
ELAV-like protein 1

1

6

Small-scale

0.618

High

1157527

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

1157536

SKAP1
Src kinase-associated phosphoprotein 1

1

20

High-throughput

0.618

High

1157548

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1157555

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

1

High-throughput

0.618

High

1157559

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.618

High

1157560

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1157561

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.618

High

1157562

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1157568

ANFY1
Rabankyrin-5

1

1

High-throughput

0.618

High

907448

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

3

High-throughput

0.611

High

1157572

PNMA2
Paraneoplastic antigen Ma2

3

4

High-throughput

0.604

High

303044

DFFB
DNA fragmentation factor subunit beta

2

0

High-throughput

0.602

High

222093

NCK2
Cytoplasmic protein NCK2

2

20

Small-scale

0.595

High

594012

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.595

High

1090133

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

13

Small-scale

0.592

High

934672

TERA
Transitional endoplasmic reticulum ATPase

2

6

High-throughput

0.584

High

1157573

HDAC5
Histone deacetylase 5

1

9

Small-scale

0.578

High

651664

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

17

High-throughput

0.575

High

1148335

KS6A1
Ribosomal protein S6 kinase alpha-1

1

18

Small-scale

0.575

High

1157519

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.575

High

1142550

PDK1
[Pyruvate dehydrogenase

2

5

Small-scale

0.571

High

516231

PAL4G
Peptidyl-prolyl cis-trans isomerase A-like 4G

2

4

High-throughput

0.552

High

214210

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

9

High-throughput

0.536

High

322663

KDM4B
Lysine-specific demethylase 4B

1

1

High-throughput

0.536

High

333024

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.536

High

402940

ANXA1
Annexin A1

1

4

High-throughput

0.536

High

415597

HSPB1
Heat shock protein beta-1

1

14

High-throughput

0.536

High

576775

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.536

High

598099

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

5

High-throughput

0.536

High

603654

JUNB
Transcription factor JunB

1

9

High-throughput

0.536

High

611893

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

687812

SYVC
Valine--tRNA ligase

1

9

High-throughput

0.536

High

688015

EF1G
Elongation factor 1-gamma

1

8

High-throughput

0.536

High

713389

SPB3
Serpin B3

1

7

High-throughput

0.536

High

730615

1433S
14-3-3 protein sigma

1

20

High-throughput

0.536

High

834457

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.536

High

874790

SPB4
Serpin B4

1

7

High-throughput

0.536

High

940252

SYMC
Methionine--tRNA ligase, cytoplasmic

1

7

High-throughput

0.536

High

1058433

CKAP4
Cytoskeleton-associated protein 4

1

10

High-throughput

0.536

High

1111014

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.536

High

1139620

SYK
Lysine--tRNA ligase

1

2

High-throughput

0.536

High

1157524

WDR74
WD repeat-containing protein 74

1

9

High-throughput

0.536

High

1157530

MOB1B
MOB kinase activator 1B

1

2

High-throughput

0.536

High

1157533

MILR1
Allergin-1

1

3

High-throughput

0.536

High

1157534

KTN1
Kinectin

1

6

High-throughput

0.536

High

1157537

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1157540

WDR20
WD repeat-containing protein 20

1

13

High-throughput

0.536

High

1157552

RUFY1
RUN and FYVE domain-containing protein 1

1

14

High-throughput

0.536

High

1157566

SYLC
Leucine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.536

High

1157570

CTNA3
Catenin alpha-3

1

3

High-throughput

0.536

High

1157574

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

656137

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

High-throughput

0.515

High

283263

ERLN1
Erlin-1

1

0

High-throughput

0.513

High

460543

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

0

High-throughput

0.513

High

629891

BTF3
Transcription factor BTF3

1

0

High-throughput

0.513

High

642556

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

665604

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.513

High

926478

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.513

High

1150536

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

1157529

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

1157531

TRM1L
tRNA

1

0

High-throughput

0.513

High

1157544

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1157553

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1157556

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

996177

EF1A1
Elongation factor 1-alpha 1

1

2

High-throughput

0.508

High

1106197

MYO9B
Unconventional myosin-IXb

1

8

High-throughput

0.508

High

861622

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

17

High-throughput

0.501

High

964306

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

143964

EST2
Cocaine esterase

1

1

High-throughput

0.489

High

337736

SGPL1
Sphingosine-1-phosphate lyase 1

1

4

High-throughput

0.489

High

773885

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.489

High

1157516

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

1157518

RABL3
Rab-like protein 3

1

7

High-throughput

0.489

High

1157526

TBCD9
TBC1 domain family member 9

1

1

High-throughput

0.489

High

1157551

F193B
Protein FAM193B

1

0

High-throughput

0.486

High

336966

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

2

Small-scale

0.479

High

345882

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

372137

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

487361

PARP1
Poly [ADP-ribose] polymerase 1

1

7

High-throughput

0.479

High

502368

H2A1
Histone H2A type 1

1

15

High-throughput

0.479

High

521710

H14
Histone H1.4

1

19

High-throughput

0.479

High

540471

LAMP1
Lysosome-associated membrane glycoprotein 1

1

5

High-throughput

0.479

High

556112

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

582817

EZRI
Ezrin

1

8

High-throughput

0.479

High

588803

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

642896

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.479

High

660078

COF1
Cofilin-1

1

2

High-throughput

0.479

High

695571

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

700651

PSA5
Proteasome subunit alpha type-5

1

1

Small-scale

0.479

High

714870

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.479

High

731338

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

768297

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

867162

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.479

High

886904

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

Small-scale

0.479

High

888457

TSP3
Thrombospondin-3

1

4

High-throughput

0.479

High

951694

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

966366

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

993894

TYB10
Thymosin beta-10

1

1

High-throughput

0.479

High

1045336

TF65
Transcription factor p65

1

10

High-throughput

0.479

High

1067388

EP300
Histone acetyltransferase p300

1

11

High-throughput

0.479

High

1138248

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1157520

CE162
Centrosomal protein of 162 kDa

1

12

High-throughput

0.479

High

1157523

RICTR
Rapamycin-insensitive companion of mTOR

1

5

High-throughput

0.479

High

1157528

CE128
Centrosomal protein of 128 kDa

1

12

High-throughput

0.479

High

1157532

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1157535

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1157542

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.479

High

1157545

VP33A
Vacuolar protein sorting-associated protein 33A

1

5

High-throughput

0.479

High

1157557

CEP44
Centrosomal protein of 44 kDa

1

1

High-throughput

0.479

High

1157558

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1157563

CPAP
Centrosomal P4.1-associated protein

1

9

High-throughput

0.479

High

1157567

HECW2
E3 ubiquitin-protein ligase HECW2

1

17

High-throughput

0.479

High

1157569

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1157571

ANC2
Anaphase-promoting complex subunit 2

1

5

High-throughput

0.479

High

421161

SCG1
Secretogranin-1

1

1

High-throughput

0.464

High

1157547

CC136
Coiled-coil domain-containing protein 136

1

12

High-throughput

0.464

High

279376

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

293750

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

1143328

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

1157549

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

91658

C9JE12
Transmembrane and ubiquitin like domain containing 1

1

1

High-throughput

0.445

High

1157522

ABLM2
Actin-binding LIM protein 2

1

4

High-throughput

0.445

High

1157565

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.445

High

416024

CP1A1
Cytochrome P450 1A1

1

2

High-throughput

0.437

High

1150585

TRAM1
Translocating chain-associated membrane protein 1

1

3

High-throughput

0.437

High

108994

G3XAN4
Translocating chain-associated membrane protein 1

1

3

High-throughput

0.407

High

1157517

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

2

High-throughput

0.407

High

1157543

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

1157550

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

0

High-throughput

0.279

Low

653336

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025