HitPredict

Interactor 1: MYPT2 (O60237)
Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)
Gene: PPP1R12B

Interactor 2: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	30344098, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 982 Hs			1 323
+	Hs
		225132 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		225133 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Mm
		906293 MYPT2_MOUSE (1-982): 6.91e-153: 479: 89.72		PP1A_MOUSE (1-323): 0: 579: 90.36
+	Hs
		737999 PP16B_HUMAN (10-383): 1.65e-86: 291: 31.70		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Hs
		737978 PP16A_HUMAN (1-310): 4.98e-81: 274: 37.46		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Hs
		906099 PP16B_HUMAN (10-383): 1.65e-86: 291: 31.70		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Dm
		115663 M9PFV2_DROME (10-466): 1e-89: 301: 28.60		PP1B_DROME (1-323): 0: 552: 82.48
+	Hs
		906079 PP16A_HUMAN (1-310): 4.98e-81: 274: 37.46		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Dm
		115662 M9PFV2_DROME (10-466): 1e-89: 301: 28.60		PP12_DROME (5-303): 0: 551: 93.31
+	Dm
		819281 Q8SY34_DROME (10-466): 1.01e-87: 299: 28.60		PP1B_DROME (1-323): 0: 552: 82.48
+	Hs
		906572 PP16B_HUMAN (10-383): 1.65e-86: 291: 31.70		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Hs
		906005 MIB1_HUMAN (2-397): 4.04e-73: 263: 18.75		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Ce
		1099876 Q95ZS1_CAEEL (62-464): 7.08e-87: 289: 28.26		GLC7A_CAEEL (1-323): 0: 549: 83.28
+	Ce
		953872 P90902_CAEEL (62-464): 1.06e-86: 288: 28.57		GLC7A_CAEEL (1-323): 0: 549: 83.28
+	Dm
		1249016 Q8SY34_DROME (10-466): 1.01e-87: 299: 28.60		Q8T0U6_DROME (19-323): 0: 535: 83.39
+	Hs
		906561 PP16A_HUMAN (1-310): 4.98e-81: 274: 37.46		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Hs
		905838 ANK2_HUMAN (38-320): 2.2e-60: 228: 21.58		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		738024 PP12C_HUMAN (224-982): 6.74e-53: 200: 17.93		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Dm
		819272 Q86R99_DROME (197-982): 2.74e-67: 243: 20.39		PP1B_DROME (1-323): 0: 552: 82.48
+	Mm
		906252 PP12C_MOUSE (224-982): 5.15e-55: 207: 18.07		PP1A_MOUSE (1-323): 0: 579: 90.36