HitPredict

Interactor 1: KLK8 (O60259)
Kallikrein-8 (hK8) (EC 3.4.21.118) (Neuropsin) (NP) (Ovasin) (Serine protease 19) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein)
Gene: KLK8

Interactor 2: VWDE (Q8N2E2)
von Willebrand factor D and EGF domain-containing protein
Gene: VWDE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 260 Hs			1 1590
+	Hs
		426531 KLK3_HUMAN (13-259): 5.18e-102: 299: 39.84		VWDE_HUMAN (1-1590): 0: 1993: 100.00
+	Hs
		1231531 KLK15_HUMAN (23-259): 7.94e-100: 293: 45.57		VWDE_HUMAN (1-1590): 0: 1993: 100.00
+	Hs
		595552 GRAH_HUMAN (28-256): 4.11e-43: 148: 37.29		VWDE_HUMAN (1-1590): 0: 1993: 100.00
+	Hs
		621377 CMA1_HUMAN (26-256): 1.08e-39: 139: 36.67		VWDE_HUMAN (1-1590): 0: 1993: 100.00
+	Hs
		980580 KLK5_HUMAN (24-259): 1.95e-97: 288: 47.48		NOTC2_HUMAN (891-1266): 6.18e-33: 142: 11.48
+	Hs
		589611 KLK2_HUMAN (12-259): 1.45e-106: 310: 41.63		JAG2_HUMAN (853-1156): 4.36e-23: 109: 10.22
+	Hs
		1329638 KLK15_HUMAN (23-259): 7.94e-100: 293: 45.57		JAG2_HUMAN (853-1156): 4.36e-23: 109: 10.22
+	Hs
		1345092 TMPS4_HUMAN (6-259): 1.55e-93: 283: 31.46		JAG2_HUMAN (853-1156): 4.36e-23: 109: 10.22
+	Mm
		378815 GRAB_MOUSE (26-259): 1.44e-89: 266: 35.27		NOTC1_MOUSE (1455-1590): 9.2e-14: 79.1: 29.19
+	Mm
		192824 CFAD_MOUSE (15-255): 5.96e-45: 153: 38.65		NOTC2_MOUSE (1285-1590): 2.77e-35: 149: 26.90
+	Hs
		486154 GRAB_HUMAN (27-256): 1.37e-39: 139: 37.08		NOTC1_HUMAN (1354-1589): 7.69e-26: 119: 26.60
+	Hs
		621387 CMA1_HUMAN (26-256): 1.08e-39: 139: 36.67		JAG2_HUMAN (853-1156): 4.36e-23: 109: 10.22
+	Mm
		372013 CFAD_MOUSE (15-255): 5.96e-45: 153: 38.65		SNED1_MOUSE (1445-1589): 1.3e-14: 81.8: 26.22
+	Mm
		371919 CFAD_MOUSE (15-255): 5.96e-45: 153: 38.65		LAMA5_MOUSE (1455-1587): 8.06e-09: 62.9: 15.71
+	Hs
		172637 GRAB_HUMAN (27-256): 1.37e-39: 139: 37.08		LAMA5_HUMAN (897-1082): 4.4e-09: 63.7: 10.90