Protein: S12A4
Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1)

Gene: S12A4, SLC12A4
Organism: Homo sapiens
Interactions: 176
UniProt ID: Q9UP95

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane
GO:0006811 - monoatomic ion transport
GO:0006884 - cell volume homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1460114

S12A6
Solute carrier family 12 member 6

5

13

Small-scale

0.908

High

1462446

S12A7
Solute carrier family 12 member 7

3

13

High-throughput

0.830

High

1432288

S12A5
Solute carrier family 12 member 5

2

13

High-throughput

0.712

High

609843

LEG3
Galectin-3

4

20

High-throughput

0.691

High

127416

LEG8
Galectin-8

3

20

High-throughput

0.667

High

1155207

EREP1
Endosomal transmembrane epsin interactor 1

3

4

High-throughput

0.667

High

376100

RASK
GTPase KRas

3

20

High-throughput

0.640

High

1294768

LYPD6
Ly6/PLAUR domain-containing protein 6

3

0

High-throughput

0.638

High

125663

LEG9
Galectin-9

4

20

High-throughput

0.630

High

127735

TR10A
Tumor necrosis factor receptor superfamily member 10A

2

6

High-throughput

0.628

High

142165

NPT3
Sodium-dependent phosphate transport protein 3

2

3

High-throughput

0.628

High

1057593

ACHD
Acetylcholine receptor subunit delta

2

5

High-throughput

0.628

High

1406368

GPR21
Probable G-protein coupled receptor 21

2

8

High-throughput

0.628

High

1446235

NRN1
Neuritin

2

2

High-throughput

0.628

High

1462445

PCDA3
Protocadherin alpha-3

2

3

High-throughput

0.628

High

1462441

AP3M1
AP-3 complex subunit mu-1

3

0

High-throughput

0.620

High

1042792

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

2

13

High-throughput

0.611

High

1231710

LEG9C
Galectin-9C

3

20

High-throughput

0.609

High

1331947

TM102
Transmembrane protein 102

2

1

High-throughput

0.606

High

1332626

I17RC
Interleukin-17 receptor C

2

0

High-throughput

0.602

High

1448887

RAB6B
Ras-related protein Rab-6B

3

20

High-throughput

0.587

High

375018

RASH
GTPase HRas

2

20

High-throughput

0.584

High

1462438

S12A4
Solute carrier family 12 member 4

1

12

Small-scale

0.584

High

1314648

M21D2
Nucleotidyltransferase MB21D2

2

3

High-throughput

0.553

High

631712

RAB6A
Ras-related protein Rab-6A

2

20

High-throughput

0.552

High

171023

CLGN
Calmegin

2

11

High-throughput

0.549

High

1328226

JAGN1
Protein jagunal homolog 1

2

3

High-throughput

0.549

High

190519

COPT1
High affinity copper uptake protein 1

1

2

High-throughput

0.536

High

248519

O10H2
Olfactory receptor 10H2

1

11

High-throughput

0.536

High

538125

HSP7C
Heat shock cognate 71 kDa protein

1

14

High-throughput

0.536

High

547345

CP19A
Aromatase

1

3

High-throughput

0.536

High

784844

ACHA7
Neuronal acetylcholine receptor subunit alpha-7

1

5

High-throughput

0.536

High

1007901

X3CL1
Fractalkine

1

1

High-throughput

0.536

High

1010548

EREP3
Protein ENTREP3

1

4

High-throughput

0.536

High

1161859

AMHR2
Anti-Muellerian hormone type-2 receptor

1

3

High-throughput

0.536

High

1195467

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

2

High-throughput

0.536

High

1203837

TTMP
TPA-induced transmembrane protein

1

4

High-throughput

0.536

High

1216665

OR2G6
Olfactory receptor 2G6

1

3

High-throughput

0.536

High

1277749

TMC4
Voltage-gated chloride channel TMC4

1

2

High-throughput

0.536

High

1328499

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

4

High-throughput

0.536

High

1339954

OR4N2
Olfactory receptor 4N2

1

9

High-throughput

0.536

High

1339967

O52I1
Olfactory receptor 52I1

1

4

High-throughput

0.536

High

1339968

OR5L1
Olfactory receptor 5L1

1

3

High-throughput

0.536

High

1339989

OR6T1
Olfactory receptor 6T1

1

4

High-throughput

0.536

High

1339994

O10S1
Olfactory receptor 10S1

1

9

High-throughput

0.536

High

1349908

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

4

High-throughput

0.536

High

1419581

ABCA2
ATP-binding cassette sub-family A member 2

1

1

High-throughput

0.536

High

1432452

TTYH1
Protein tweety homolog 1

1

5

High-throughput

0.536

High

1438495

RXFP1
Relaxin receptor 1

1

5

High-throughput

0.536

High

1446134

KCMB3
Calcium-activated potassium channel subunit beta-3

1

1

High-throughput

0.536

High

1446724

TMM9B
Transmembrane protein 9B

1

1

High-throughput

0.536

High

1448619

PCDBG
Protocadherin beta-16

1

6

High-throughput

0.536

High

1462443

O10H1
Olfactory receptor 10H1

1

11

High-throughput

0.536

High

1462444

PCDGL
Protocadherin gamma-C4

1

6

High-throughput

0.536

High

1462447

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

390812

TFR1
Transferrin receptor protein 1

1

4

High-throughput

0.515

High

880982

MTR1B
Melatonin receptor type 1B

1

5

High-throughput

0.508

High

49828

CLRN2
Clarin-2

1

3

High-throughput

0.489

High

317100

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

2

High-throughput

0.489

High

788506

DHB3
17-beta-hydroxysteroid dehydrogenase type 3

1

4

High-throughput

0.489

High

1126387

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

4

High-throughput

0.489

High

1185370

LEG9B
Galectin-9B

1

20

High-throughput

0.489

High

1392313

ZDH12
Palmitoyltransferase ZDHHC12

1

9

High-throughput

0.489

High

1454530

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

4

High-throughput

0.489

High

126875

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

133819

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

1

High-throughput

0.479

High

136999

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

5

High-throughput

0.479

High

180106

BET1
BET1 homolog

1

9

High-throughput

0.479

High

189929

STX7
Syntaxin-7

1

15

High-throughput

0.479

High

218965

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

226264

STX6
Syntaxin-6

1

9

High-throughput

0.479

High

341174

DIRA3
GTP-binding protein Di-Ras3

1

16

High-throughput

0.479

High

374283

RASN
GTPase NRas

1

20

High-throughput

0.479

High

463841

LYN
Tyrosine-protein kinase Lyn

1

11

Small-scale

0.479

High

466528

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

562492

LAMP2
Lysosome-associated membrane glycoprotein 2

1

14

High-throughput

0.479

High

581375

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

601500

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

604272

CXA1
Gap junction alpha-1 protein

1

10

High-throughput

0.479

High

631564

RAB5A
Ras-related protein Rab-5A

1

20

High-throughput

0.479

High

845862

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.479

High

901107

RAB5C
Ras-related protein Rab-5C

1

20

High-throughput

0.479

High

901683

RAB7A
Ras-related protein Rab-7a

1

20

High-throughput

0.479

High

910254

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

953760

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955758

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

956542

RAB2A
Ras-related protein Rab-2A

1

20

High-throughput

0.479

High

962639

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

975322

ARF6
ADP-ribosylation factor 6

1

10

High-throughput

0.479

High

978407

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

988828

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1015907

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1145174

RAB35
Ras-related protein Rab-35

1

17

High-throughput

0.479

High

1151932

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1233580

LTOR1
Ragulator complex protein LAMTOR1

1

6

High-throughput

0.479

High

1271054

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1330978

CGAS
Cyclic GMP-AMP synthase

1

4

High-throughput

0.479

High

1366914

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1433581

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1438246

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1453928

TM216
Transmembrane protein 216

1

2

High-throughput

0.479

High

1462439

LAMP3
Lysosome-associated membrane glycoprotein 3

1

14

High-throughput

0.479

High

124853

AIP
AH receptor-interacting protein

1

9

High-throughput

0.445

High

136563

GOLI4
Golgi integral membrane protein 4

1

1

High-throughput

0.445

High

213345

ADCY6
Adenylate cyclase type 6

1

6

High-throughput

0.445

High

243836

ADCY3
Adenylate cyclase type 3

1

5

High-throughput

0.445

High

291592

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.445

High

344044

HS74L
Heat shock 70 kDa protein 4L

1

20

High-throughput

0.445

High

348000

BAG3
BAG family molecular chaperone regulator 3

1

10

High-throughput

0.445

High

364030

EGFR
Epidermal growth factor receptor

1

16

High-throughput

0.445

High

462049

HS90A
Heat shock protein HSP 90-alpha

1

9

High-throughput

0.445

High

468920

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.445

High

600963

HSP76
Heat shock 70 kDa protein 6

1

14

High-throughput

0.445

High

761539

HS71L
Heat shock 70 kDa protein 1-like

1

14

High-throughput

0.445

High

761931

HSP74
Heat shock 70 kDa protein 4

1

20

High-throughput

0.445

High

931162

HSP72
Heat shock-related 70 kDa protein 2

1

14

High-throughput

0.445

High

1038727

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

16

High-throughput

0.445

High

1106126

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

16

High-throughput

0.445

High

1133820

SL9A5
Sodium/hydrogen exchanger 5

1

2

High-throughput

0.445

High

1158725

DPYL2
Dihydropyrimidinase-related protein 2

1

1

High-throughput

0.445

High

1207910

S27A3
Long-chain fatty acid transport protein 3

1

6

High-throughput

0.445

High

1238388

RETST
All-trans-retinol 13,14-reductase

1

9

High-throughput

0.445

High

1244126

TMM88
Transmembrane protein 88

1

1

High-throughput

0.445

High

1337723

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.445

High

1365271

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.445

High

1386235

ASTRA
Protein Aster-A

1

1

High-throughput

0.445

High

1405317

PKP4
Plakophilin-4

1

2

High-throughput

0.445

High

1405914

DNJC7
DnaJ homolog subfamily C member 7

1

16

High-throughput

0.445

High

1412721

ESYT1
Extended synaptotagmin-1

1

7

High-throughput

0.445

High

1435150

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

13

High-throughput

0.445

High

1438435

POPD2
Popeye domain-containing protein 2

1

3

High-throughput

0.445

High

1445752

WDR6
tRNA

1

2

High-throughput

0.445

High

1458945

DNJB4
DnaJ homolog subfamily B member 4

1

6

High-throughput

0.445

High

1461156

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

1

High-throughput

0.445

High

1461354

BAG5
BAG family molecular chaperone regulator 5

1

10

High-throughput

0.445

High

1462440

S27A6
Long-chain fatty acid transport protein 6

1

6

High-throughput

0.445

High

631023

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.437

High

976666

RB11A
Ras-related protein Rab-11A

1

9

High-throughput

0.437

High

1227715

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

1256107

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1293207

TMM17
Transmembrane protein 17

1

6

High-throughput

0.437

High

1396866

SNX27
Sorting nexin-27

1

3

High-throughput

0.437

High

1450138

OTULL
Inactive ubiquitin thioesterase OTULINL

1

2

High-throughput

0.437

High

1459321

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

1462442

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.437

High

72685

UPK3L
Uroplakin-3b-like protein 1

1

0

High-throughput

0.426

High

1017822

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.426

High

1389936

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.426

High

136449

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

14

High-throughput

0.407

High

298977

DNJB5
DnaJ homolog subfamily B member 5

1

6

High-throughput

0.407

High

347416

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.407

High

414857

P53
Cellular tumor antigen p53

1

2

High-throughput

0.407

High

679289

DNJB1
DnaJ homolog subfamily B member 1

1

6

High-throughput

0.407

High

731704

STIP1
Stress-induced-phosphoprotein 1

1

12

High-throughput

0.407

High

895979

F10A1
Hsc70-interacting protein

1

16

High-throughput

0.407

High

1119466

CASP
Protein CASP

1

5

High-throughput

0.407

High

1158602

CDC37
Hsp90 co-chaperone Cdc37

1

3

High-throughput

0.407

High

1200383

RAB6D
Ras-related protein Rab-6D

1

20

High-throughput

0.407

High

1357346

THEM6
Protein THEM6

1

3

High-throughput

0.407

High

1364895

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

13

High-throughput

0.407

High

1405820

TTC1
Tetratricopeptide repeat protein 1

1

17

High-throughput

0.407

High

1409541

DPYL5
Dihydropyrimidinase-related protein 5

1

1

High-throughput

0.407

High

1462268

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

High-throughput

0.407

High

70534

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

948405

KR122
Keratin-associated protein 12-2

2

0

High-throughput

0.316

High

1186542

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.316

High

1330252

ZN655
Zinc finger protein 655

2

0

High-throughput

0.316

High

1418295

CNFN
Cornifelin

2

0

High-throughput

0.316

High

1249403

CWC27
Spliceosome-associated protein CWC27 homolog

1

0

High-throughput

0.249

Low

1461671

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.249

Low

1250476

MCAF1
Activating transcription factor 7-interacting protein 1

1

0

High-throughput

0.238

Low

553096

PIP
Prolactin-inducible protein

1

0

High-throughput

0.232

Low

1413835

HGH1
Protein HGH1 homolog

1

0

High-throughput

0.232

Low

1437980

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.232

Low

1459152

PISD
Phosphatidylserine decarboxylase proenzyme, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025