Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN
Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.99 | 1.00 | 0.996 |
The method score is based on:
Property | Details |
---|---|
Experiments | 25375667, 25527291, 26254304, 25969509, 26631732, 26116755, 28414322, 28276439, 24647965, 29180628, 29987020, 28689991, 27096575, 27312108, 29530980, 29995846, 30446597, 25959826, 32193420, 31432739 and 28 others
more... |
Identification Methods | enzymatic study, affinity chromatography technology, pull down, proximity labelling technology, nuclear magnetic resonance, isothermal titration calorimetry |
Interaction Type | direct interaction, physical association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | ubiquitin~ubiquitin, ubiquitin~zf-RING_12, ubiquitin~zf-RING_14, zf-RING_12~zf-RING_12, zf-RING_12~zf-RING_14 |
Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000151 - ubiquitin ligase complex GO:0000209 - protein polyubiquitination GO:0000266 - mitochondrial fission GO:0000422 - autophagy of mitochondrion and 137 others more... |
Homologous interactions | 18 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024