HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TOM1 (O60784)
Target of Myb1 membrane trafficking protein (Target of Myb protein 1)
Gene: TOM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GAT~ubiquitin, VHS~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043130 - ubiquitin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 492
+	Hs
		159798 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HGS_HUMAN (10-465): 5.12e-76: 255: 17.90
+	Hs
		226084 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STAM2_HUMAN (1-454): 3.15e-74: 245: 19.61
+	Hs
		241137 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TOM1_HUMAN (1-492): 5.19e-178: 510: 100.00
+	Hs
		475949 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TM1L2_HUMAN (1-492): 2.32e-147: 432: 61.45
+	Hs
		475230 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		GGA1_HUMAN (12-450): 6.7e-91: 291: 21.37
+	Hs
		160178 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		HGS_HUMAN (10-465): 5.12e-76: 255: 17.90
+	Hs
		475215 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		GGA3_HUMAN (12-476): 3.9e-84: 276: 21.28
+	Bt
		477668 UBC_BOVIN (1-149): 6.08e-49: 179: 19.33		Q58CQ6_BOVIN (12-375): 2.46e-91: 286: 23.06
+	Sc
		477270 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		GGA2_YEAST (11-448): 3.49e-77: 254: 19.30
+	Sc
		477454 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		GGA1_YEAST (10-454): 4.3e-77: 253: 20.70
+	Hs
		272789 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TM1L1_HUMAN (7-487): 1.65e-105: 324: 29.66
+	Hs
		276992 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		STAM2_HUMAN (1-454): 3.15e-74: 245: 19.61
+	Hs
		476138 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		STAM1_HUMAN (1-477): 6.09e-92: 291: 19.27
+	Hs
		476541 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GGA1_HUMAN (12-450): 6.7e-91: 291: 21.37
+	Hs
		476481 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GGA3_HUMAN (12-476): 3.9e-84: 276: 21.28
+	At
		285943 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TOL6_ARATH (18-428): 4.69e-84: 274: 23.27
+	Hs
		3258 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		A0A0S2Z4Q4_HUMAN (10-188): 2.46e-44: 167: 30.56
+	Hs
		159860 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		HGS_HUMAN (10-465): 5.12e-76: 255: 17.90
+	Hs
		276993 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		STAM2_HUMAN (1-454): 3.15e-74: 245: 19.61
+	At
		1092009 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TOL5_ARATH (13-350): 7.92e-73: 239: 20.65