HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TOM40 (O96008)
Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5)
Gene: TOMM40

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	29180628, 24149440, 30629163
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 361
+	Hs
		226775 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		VDAC2_HUMAN (67-360): 7.67e-85: 260: 10.82
+	Hs
		229093 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		VDAC3_HUMAN (77-360): 1.86e-84: 259: 9.97
+	Hs
		226516 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		VDAC1_HUMAN (77-359): 5.38e-75: 235: 12.93
+	Hs
		476591 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		VDAC3_HUMAN (77-360): 1.86e-84: 259: 9.97
+	Hs
		475333 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		VDAC1_HUMAN (77-359): 5.38e-75: 235: 12.93
+	At
		1092039 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		VDAC2_ARATH (78-360): 6.27e-66: 211: 13.99