HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 591
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94
+	Hs
		227317 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK4_HUMAN (298-588): 1.44e-122: 372: 35.50
+	Hs
		226918 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KS6A3_HUMAN (265-591): 5.2e-113: 355: 24.27
+	Hs
		227531 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39
+	Hs
		228945 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK26_HUMAN (315-574): 2.21e-52: 186: 38.31
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94
+	Hs
		475012 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		STK4_HUMAN (298-588): 1.44e-122: 372: 35.50
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (320-589): 3.69e-133: 400: 28.00
+	Hs
		227338 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67
+	At
		955189 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN11_ARATH (320-589): 1.19e-128: 388: 26.62