HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: KPYM (P14618)
Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58)
Gene: PKM

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.735

Property	Details
Experiments	26975375, 25959826, 32929329, 34671086, 35509820, 35256949
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 531
+	Hs
		475298 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KPYM_HUMAN (1-531): 0: 801: 100.00
+	At
		1092008 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9FFP6_ARATH (41-530): 0: 602: 45.26
+	At
		1092052 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9FM97_ARATH (41-530): 0: 597: 44.27
+	At
		1092343 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9SJQ0_ARATH (33-519): 0: 528: 33.14
+	At
		1091940 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q94KE3_ARATH (33-519): 0: 523: 33.92