HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: VINC (P18206)
Vinculin (Metavinculin) (MV)
Gene: VCL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35509820, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008013 - beta-catenin binding GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1134
+	Hs
		226666 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CTNA1_HUMAN (5-899): 1.05e-65: 241: 15.48
+	Hs
		229154 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TLN1_HUMAN (33-1112): 2.04e-52: 204: 12.22
+	Hs
		229160 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TLN2_HUMAN (46-1116): 6.3e-11: 69.3: 12.30
+	Hs
		228508 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FYCO1_HUMAN (127-1051): 1.54e-09: 64.7: 11.63