HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.83 0.60 0.709

The method score is based on:

Property Details
Experiments 25959826, 32929329, 35509820, 35256949, 24244333
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0034976 - response to endoplasmic reticulum stress
GO:0036503 - ERAD pathway
and 2 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 465
Hs

1 803
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ At
+ At
+ At
+ Sc
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024