Protein: SC6A3
Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3)

Gene: SC6A3, SLC6A3
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q01959

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0005102 - signaling receptor binding
GO:0005326 - neurotransmitter transmembrane transporter activity
GO:0005330 - dopamine:sodium symporter activity
GO:0005334 - norepinephrine:sodium symporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

791304

SYUA
Alpha-synuclein

6

10

Small-scale

0.729

High

1033927

STX1A
Syntaxin-1A

2

15

Small-scale

0.624

High

861578

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

2

Small-scale

0.595

High

1033929

WLS
Protein wntless homolog

2

0

Small-scale

0.585

High

1033949

PICK1
PRKCA-binding protein

1

4

Small-scale

0.582

High

870353

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

9

High-throughput

0.575

High

226480

SNG3
Synaptogyrin-3

1

3

Small-scale

0.561

High

869726

MTR1A
Melatonin receptor type 1A

1

4

High-throughput

0.541

High

1033923

SNTA1
Alpha-1-syntrophin

1

18

Small-scale

0.527

High

212720

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

1

Small-scale

0.527

High

186900

GPR37
Prosaposin receptor GPR37

1

4

Small-scale

0.515

High

572436

DRD2
D(2) dopamine receptor

1

3

Small-scale

0.515

High

130074

PGRC1
Membrane-associated progesterone receptor component 1

1

4

Small-scale

0.479

High

181309

PGRC2
Membrane-associated progesterone receptor component 2

1

4

Small-scale

0.479

High

241434

PRKN
E3 ubiquitin-protein ligase parkin

1

2

Small-scale

0.479

High

467460

4F2
Amino acid transporter heavy chain SLC3A2

1

2

Small-scale

0.479

High

839746

EPS15
Epidermal growth factor receptor substrate 15

1

5

Small-scale

0.479

High

1033921

VMAT2
Synaptic vesicular amine transporter

1

1

Small-scale

0.479

High

1033922

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

3

High-throughput

0.479

High

1033924

CUL1
Cullin-1

1

1

Small-scale

0.479

High

1033956

FBXL2
F-box/LRR-repeat protein 2

1

3

Small-scale

0.479

High

1033957

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

Small-scale

0.479

High

1033959

EPN1
Epsin-1

1

1

Small-scale

0.479

High

996664

TBA1B
Tubulin alpha-1B chain

1

0

Small-scale

0.458

High

1033944

TBB1
Tubulin beta-1 chain

1

0

Small-scale

0.458

High

1033939

RIT2
GTP-binding protein Rit2

1

20

Small-scale

0.457

High

163285

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

3

High-throughput

0.445

High

183142

GNPAT
Dihydroxyacetone phosphate acyltransferase

1

1

High-throughput

0.445

High

957913

RAB14
Ras-related protein Rab-14

1

10

High-throughput

0.445

High

1033925

SCRIB
Protein scribble homolog

1

10

High-throughput

0.445

High

1033926

DHC24
Delta(24)-sterol reductase

1

4

High-throughput

0.445

High

1033931

AN13D
Ankyrin repeat domain-containing protein 13D

1

5

High-throughput

0.445

High

1033933

CNNM3
Metal transporter CNNM3

1

2

High-throughput

0.445

High

1033935

PO210
Nuclear pore membrane glycoprotein 210

1

5

High-throughput

0.445

High

1033938

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

2

High-throughput

0.445

High

1033940

ESYT1
Extended synaptotagmin-1

1

6

High-throughput

0.445

High

1033941

NDC1
Nucleoporin NDC1

1

1

High-throughput

0.445

High

1033945

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

2

High-throughput

0.445

High

1033946

RDH14
Retinol dehydrogenase 14

1

4

High-throughput

0.445

High

1033947

WDR6
tRNA

1

2

High-throughput

0.445

High

1033948

RTN4
Reticulon-4

1

5

High-throughput

0.445

High

1033951

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

13

High-throughput

0.445

High

1033952

LIN7C
Protein lin-7 homolog C

1

18

High-throughput

0.445

High

1033954

PALS2
Protein PALS2

1

8

High-throughput

0.445

High

1033958

UBIA1
UbiA prenyltransferase domain-containing protein 1

1

2

High-throughput

0.445

High

1033936

PIEZ1
Piezo-type mechanosensitive ion channel component 1

1

0

High-throughput

0.426

High

1033953

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.426

High

168227

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.407

High

847391

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

2

High-throughput

0.407

High

1033928

GNPTA
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

1

1

High-throughput

0.407

High

1033932

CP4X1
Cytochrome P450 4X1

1

2

High-throughput

0.407

High

1033934

RDH11
Retinol dehydrogenase 11

1

3

High-throughput

0.407

High

1033943

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.407

High

1033950

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

1

13

High-throughput

0.407

High

1033955

GNPTG
N-acetylglucosamine-1-phosphotransferase subunit gamma

1

3

High-throughput

0.407

High

129862

GET1
Guided entry of tail-anchored proteins factor 1

1

0

High-throughput

0.232

Low

223722

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

0

High-throughput

0.232

Low

1033930

MIC10
MICOS complex subunit MIC10

1

0

High-throughput

0.232

Low

1033937

DMAC1
Distal membrane-arm assembly complex protein 1

1

0

High-throughput

0.232

Low

1033942

HIG2A
HIG1 domain family member 2A, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025