HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: H12 (P16403)
Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)
Gene: H1-2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35256949, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 213
+	Hs
		226442 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		H13_HUMAN (1-181): 4.78e-25: 99.5: 82.42
+	Hs
		226527 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		H1T_HUMAN (1-183): 5.25e-24: 96.4: 53.40
+	Hs
		226340 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		H14_HUMAN (1-172): 4.96e-18: 80.6: 88.37
+	Hs
		312459 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		H14_HUMAN (1-172): 4.96e-18: 80.6: 88.37
+	Hs
		475268 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		H14_HUMAN (1-172): 4.96e-18: 80.6: 88.37