HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RFC4 (P35249)
Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37)
Gene: RFC4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35256949, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0005634 - nucleus
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 363
+	Hs
		226671 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC2_HUMAN (1-358): 8.75e-87: 267: 33.80
+	Hs
		226739 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC5_HUMAN (28-356): 5.29e-81: 252: 36.67
+	Hs
		226740 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC3_HUMAN (39-361): 1.07e-66: 216: 24.28
+	Hs
		475409 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RFC2_HUMAN (1-358): 8.75e-87: 267: 33.80
+	Hs
		475441 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RFC5_HUMAN (28-356): 5.29e-81: 252: 36.67
+	Hs
		475442 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RFC3_HUMAN (39-361): 1.07e-66: 216: 24.28