Protein: CHIP
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)

Gene: CHIP, Stub1
Organism: Mus musculus
Interactions: 45
UniProt ID: Q9WUD1

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000165 - MAPK cascade
GO:0000209 - protein polyubiquitination
GO:0001664 - G protein-coupled receptor binding
GO:0002931 - response to ischemia

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1490151

CHIP
E3 ubiquitin-protein ligase CHIP

4

19

Small-scale

0.882

High

989295

HSP7C
Heat shock cognate 71 kDa protein

2

20

Small-scale

0.776

High

237393

ILK
Scaffold protein ILK

2

8

Small-scale

0.650

High

1408797

UBX2A
UBX domain-containing protein 2A

2

2

Small-scale

0.620

High

609035

HS71B
Heat shock 70 kDa protein 1B

1

20

Small-scale

0.618

High

801659

HSPA9
Stress-70 protein, mitochondrial

1

20

Small-scale

0.618

High

1440893

HYOU1
Hypoxia up-regulated protein 1

1

20

Small-scale

0.618

High

999901

TRAF6
TNF receptor-associated factor 6

2

13

Small-scale

0.601

High

1341552

DAAF4
Dynein axonemal assembly factor 4

2

19

Small-scale

0.586

High

884996

CDK5
Cyclin-dependent kinase 5

1

10

Small-scale

0.578

High

551516

A4
Amyloid-beta precursor protein

2

3

Small-scale

0.563

High

1283227

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.536

High

1298716

BAG5
BAG family molecular chaperone regulator 5

1

7

Small-scale

0.536

High

431379

SRC
Proto-oncogene tyrosine-protein kinase Src

1

10

Small-scale

0.515

High

728543

AKT1
RAC-alpha serine/threonine-protein kinase

1

8

Small-scale

0.515

High

1040017

KPCZ
Protein kinase C zeta type

1

10

Small-scale

0.515

High

1209207

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

13

Small-scale

0.515

High

61773

A3KN90
Mineralocorticoid receptor

1

20

Small-scale

0.479

High

109299

G5E8L8
mitogen-activated protein kinase kinase kinase

1

10

Small-scale

0.479

High

530944

TAU
Microtubule-associated protein tau

1

17

Small-scale

0.479

High

547287

HS90B
Heat shock protein HSP 90-beta

1

20

Small-scale

0.479

High

586160

TFE2
Transcription factor E2-alpha

1

2

Small-scale

0.479

High

594825

IL4RA
Interleukin-4 receptor subunit alpha

1

9

Small-scale

0.479

High

688520

TWST1
Twist-related protein 1

1

3

High-throughput

0.479

High

940754

AQP2
Aquaporin-2

1

3

Small-scale

0.479

High

1221551

TRAF3
TNF receptor-associated factor 3

1

15

Small-scale

0.479

High

1222276

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

9

Small-scale

0.479

High

1260686

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

11

Small-scale

0.479

High

1282743

FACD2
Fanconi anemia group D2 protein homolog

1

2

High-throughput

0.479

High

1283466

WDTC1
WD and tetratricopeptide repeats protein 1

1

19

High-throughput

0.479

High

1354133

SP7
Transcription factor Sp7

1

11

Small-scale

0.479

High

1408714

FOXP3
Forkhead box protein P3

1

2

Small-scale

0.479

High

1423822

ATX3
Ataxin-3

1

4

Small-scale

0.479

High

1424387

TLR9
Toll-like receptor 9

1

6

Small-scale

0.479

High

1455826

CAF1A
Chromatin assembly factor 1 subunit A

1

8

High-throughput

0.479

High

1490152

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

18

Small-scale

0.479

High

1317906

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.458

High

1341604

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

1

0

Small-scale

0.458

High

237112

SYUA
Alpha-synuclein

1

2

Small-scale

0.445

High

1296765

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

12

High-throughput

0.445

High

399218

CFAD
Complement factor D

1

2

High-throughput

0.437

High

1222673

ACVL1
Activin receptor type-1-like

1

2

High-throughput

0.437

High

1455799

TLR4
Toll-like receptor 4

1

6

Small-scale

0.437

High

963161

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025