HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: GRP75 (P38646)
Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)
Gene: HSPA9

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	21640711, 32929329, 35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0031072 - heat shock protein binding GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 679
+	Hs
		226353 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		226663 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HS71L_HUMAN (49-673): 0: 883: 47.59
+	Hs
		226452 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HSP76_HUMAN (49-673): 0: 875: 48.68
+	Hs
		226336 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HS71A_HUMAN (51-652): 0: 873: 49.27
+	Hs
		226968 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HSP72_HUMAN (50-653): 0: 868: 49.11
+	Mm
		1143065 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		HS71A_MOUSE (51-652): 0: 867: 48.94
+	Hs
		312461 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		312496 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		HS71L_HUMAN (49-673): 0: 883: 47.59
+	Hs
		312505 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Hs
		474905 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		475281 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	At
		1092279 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		HSP7E_ARATH (54-673): 0: 868: 48.06
+	Sc
		477076 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		HSP77_YEAST (37-653): 0: 785: 66.61
+	At
		612331 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		HS702_ARATH (48-673): 0: 862: 47.94
+	Hs
		226351 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		312460 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		475278 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		BIP_HUMAN (53-677): 0: 566: 50.55