Protein: TTC3
E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)

Gene: TTC3
Organism: Homo sapiens
Interactions: 120
UniProt ID: P53804

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

923579

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

19

Small-scale

0.778

High

507717

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

Small-scale

0.747

High

923620

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

19

Small-scale

0.647

High

923613

DC2L1
Cytoplasmic dynein 2 light intermediate chain 1

2

3

High-throughput

0.628

High

923610

RN214
RING finger protein 214

2

2

High-throughput

0.611

High

728129

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.609

High

421777

A4
Amyloid-beta precursor protein

2

5

High-throughput

0.608

High

923639

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

20

Small-scale

0.578

High

761601

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.552

High

728565

AKT2
RAC-beta serine/threonine-protein kinase

1

7

Small-scale

0.543

High

154657

ARI1A
AT-rich interactive domain-containing protein 1A

1

7

High-throughput

0.541

High

176953

CE290
Centrosomal protein of 290 kDa

1

9

High-throughput

0.541

High

177827

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

18

High-throughput

0.541

High

342802

HERC2
E3 ubiquitin-protein ligase HERC2

1

20

High-throughput

0.541

High

415454

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.541

High

551701

HARS1
Histidine--tRNA ligase, cytoplasmic

1

8

High-throughput

0.541

High

578290

ETS2
Protein C-ets-2

1

4

High-throughput

0.541

High

587595

DESP
Desmoplakin

1

10

High-throughput

0.541

High

639693

TAF1
Transcription initiation factor TFIID subunit 1

1

12

High-throughput

0.541

High

658666

JAK1
Tyrosine-protein kinase JAK1

1

16

High-throughput

0.541

High

685134

PAX6
Paired box protein Pax-6

1

5

High-throughput

0.541

High

720450

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.541

High

823873

PBX2
Pre-B-cell leukemia transcription factor 2

1

1

High-throughput

0.541

High

828632

MDHC
Malate dehydrogenase, cytoplasmic

1

5

High-throughput

0.541

High

903291

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

8

High-throughput

0.541

High

906482

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

10

High-throughput

0.541

High

923575

NR1H2
Oxysterols receptor LXR-beta

1

11

High-throughput

0.541

High

923576

PKNX1
Homeobox protein PKNOX1

1

1

High-throughput

0.541

High

923577

STXB1
Syntaxin-binding protein 1

1

3

High-throughput

0.541

High

923578

1433E
14-3-3 protein epsilon

1

6

High-throughput

0.541

High

923580

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

9

High-throughput

0.541

High

923581

PRKDC
DNA-dependent protein kinase catalytic subunit

1

12

High-throughput

0.541

High

923582

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

11

High-throughput

0.541

High

923583

AK17A
A-kinase anchor protein 17A

1

5

High-throughput

0.541

High

923584

DYST
Dystonin

1

11

High-throughput

0.541

High

923586

PSME1
Proteasome activator complex subunit 1

1

2

High-throughput

0.541

High

923587

ZO1
Tight junction protein 1

1

5

High-throughput

0.541

High

923589

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

12

High-throughput

0.541

High

923593

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

10

High-throughput

0.541

High

923594

CKAP5
Cytoskeleton-associated protein 5

1

10

High-throughput

0.541

High

923597

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

13

High-throughput

0.541

High

923601

UBR4
E3 ubiquitin-protein ligase UBR4

1

4

High-throughput

0.541

High

923607

CAPS2
Calcium-dependent secretion activator 2

1

2

High-throughput

0.541

High

923608

LIPB1
Liprin-beta-1

1

6

High-throughput

0.541

High

923616

TITIN
Titin

1

5

High-throughput

0.541

High

923618

CSN5
COP9 signalosome complex subunit 5

1

13

High-throughput

0.541

High

923621

EXOC4
Exocyst complex component 4

1

1

High-throughput

0.541

High

923624

LCOR
Ligand-dependent corepressor

1

1

High-throughput

0.541

High

923627

FMNL2
Formin-like protein 2

1

2

High-throughput

0.541

High

923628

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

8

High-throughput

0.541

High

923631

WAC
WW domain-containing adapter protein with coiled-coil

1

7

High-throughput

0.541

High

923635

XRN2
5'-3' exoribonuclease 2

1

5

High-throughput

0.541

High

923638

KANL2
KAT8 regulatory NSL complex subunit 2

1

1

High-throughput

0.541

High

923641

JADE2
E3 ubiquitin-protein ligase Jade-2

1

3

High-throughput

0.541

High

923644

RAI14
Ankycorbin

1

17

High-throughput

0.541

High

923645

MO4L1
Mortality factor 4-like protein 1

1

1

High-throughput

0.541

High

923646

NUFP1
FMR1-interacting protein NUFIP1

1

1

High-throughput

0.541

High

923648

CAPS1
Calcium-dependent secretion activator 1

1

2

High-throughput

0.541

High

923651

FBX7
F-box only protein 7

1

2

High-throughput

0.541

High

923652

TRAF6
TNF receptor-associated factor 6

1

14

High-throughput

0.541

High

74457

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

10

High-throughput

0.536

High

184279

NPHP1
Nephrocystin-1

1

2

High-throughput

0.536

High

323976

CSTN1
Calsyntenin-1

1

4

High-throughput

0.536

High

341919

CEP43
Centrosomal protein 43

1

1

High-throughput

0.536

High

625264

CSK22
Casein kinase II subunit alpha'

1

14

High-throughput

0.536

High

923588

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

7

High-throughput

0.536

High

923611

KI18A
Kinesin-like protein KIF18A

1

3

High-throughput

0.536

High

923612

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.536

High

923623

DYL2
Dynein light chain 2, cytoplasmic

1

5

High-throughput

0.536

High

923629

SMC6
Structural maintenance of chromosomes protein 6

1

12

High-throughput

0.536

High

923632

DUS16
Dual specificity protein phosphatase 16

1

3

High-throughput

0.536

High

923636

DSN1
Kinetochore-associated protein DSN1 homolog

1

1

High-throughput

0.536

High

923640

PAR6A
Partitioning defective 6 homolog alpha

1

7

High-throughput

0.536

High

923649

SRPK3
SRSF protein kinase 3

1

10

High-throughput

0.536

High

923650

AKT3
RAC-gamma serine/threonine-protein kinase

1

7

Small-scale

0.534

High

239416

3BP5
SH3 domain-binding protein 5

1

0

High-throughput

0.518

High

914936

THOP1
Thimet oligopeptidase

1

0

High-throughput

0.518

High

923602

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

1

0

High-throughput

0.518

High

923614

WHAMM
WASP homolog-associated protein with actin, membranes and microtubules

1

0

High-throughput

0.518

High

923615

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.518

High

923619

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

High-throughput

0.518

High

923633

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.518

High

923637

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.518

High

923605

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.513

High

923625

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

923585

UBE3A
Ubiquitin-protein ligase E3A

1

20

High-throughput

0.508

High

598044

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

5

High-throughput

0.494

High

923592

SHRM2
Protein Shroom2

1

2

High-throughput

0.494

High

923596

SPRL1
SPARC-like protein 1

1

4

High-throughput

0.494

High

923606

DAAM2
Disheveled-associated activator of morphogenesis 2

1

3

High-throughput

0.494

High

630232

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

14

High-throughput

0.489

High

900741

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.489

High

923599

KRBX4
KRAB domain-containing protein 4

1

8

High-throughput

0.489

High

923600

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

1

High-throughput

0.489

High

822549

VHL
von Hippel-Lindau disease tumor suppressor

1

2

Small-scale

0.481

High

295121

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

8

High-throughput

0.479

High

345559

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.479

High

403935

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

437129

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.479

High

577419

ETS1
Protein C-ets-1

1

4

High-throughput

0.479

High

830402

CCNF
Cyclin-F

1

10

High-throughput

0.479

High

872107

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.479

High

923590

BIRC3
Baculoviral IAP repeat-containing protein 3

1

9

High-throughput

0.479

High

923591

CUL3
Cullin-3

1

9

High-throughput

0.479

High

923595

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

8

High-throughput

0.479

High

923609

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

19

High-throughput

0.479

High

923617

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

923626

ZDH15
Palmitoyltransferase ZDHHC15

1

1

Small-scale

0.479

High

923630

DNJC7
DnaJ homolog subfamily C member 7

1

17

High-throughput

0.479

High

923634

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

16

High-throughput

0.479

High

923647

ANC2
Anaphase-promoting complex subunit 2

1

13

High-throughput

0.479

High

834282

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.458

High

923598

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

923604

MCAF1
Activating transcription factor 7-interacting protein 1

1

11

High-throughput

0.457

High

923622

CHP3
Calcineurin B homologous protein 3

1

1

High-throughput

0.457

High

923642

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.457

High

923643

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.438

High

124282

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.437

High

923574

DPOG1
DNA polymerase subunit gamma-1

1

0

Small-scale

0.288

High

923603

LEU7
Leukemia-associated protein 7

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025