HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: KI67 (P46013)
Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)
Gene: MKI67

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 3256
+	Hs
		475463 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KI67_HUMAN (1-3256): 0: 1046: 100.00
+	Hs
		227149 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MAP1A_HUMAN (139-2564): 8.72e-104: 377: 10.33
+	Hs
		227460 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14
+	Hs
		226795 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59
+	Hs
		226818 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRC2A_HUMAN (513-2601): 5.1e-21: 104: 7.93
+	Hs
		228104 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63
+	Hs
		229078 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SRRM2_HUMAN (1748-3241): 1.64e-18: 96: 8.53
+	Hs
		228019 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AGRG4_HUMAN (413-2504): 5.58e-15: 84.4: 12.66
+	Hs
		228210 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TITIN_HUMAN (52-1221): 1.55e-13: 80: 7.85
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (78-1640): 1.72e-10: 69.6: 6.73
+	Hs
		476121 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MUC16_HUMAN (48-2581): 3.63e-63: 244: 8.34
+	At
		1092118 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9LIE8_ARATH (2465-3235): 4.54e-28: 127: 10.05
+	Hs
		475943 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OTOG_HUMAN (489-1062): 1.17e-21: 106: 9.29
+	Hs
		476412 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MUC5B_HUMAN (99-1603): 7.19e-10: 67.5: 8.52