HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: EFTU (P49411)
Elongation factor Tu, mitochondrial (EF-Tu) (P43)
Gene: TUFM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	25959826, 32929329, 35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 455
+	Hs
		227130 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EF1A1_HUMAN (54-442): 3.32e-133: 393: 28.73
+	Hs
		227242 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EF1A2_HUMAN (54-442): 5.65e-133: 393: 29.62
+	Hs
		475481 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		EFTU_HUMAN (1-455): 1.08e-173: 496: 100.00
+	Hs
		312566 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		EF1A1_HUMAN (54-442): 3.32e-133: 393: 28.73
+	Sc
		367642 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		EF1A_YEAST (54-442): 1.29e-134: 397: 28.19
+	At
		570784 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		EFTU_ARATH (12-443): 2e-154: 448: 48.99
+	Xl
		568008 Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33		EF1A2_XENLA (54-442): 8e-132: 390: 28.73
+	Hs
		475654 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		EF1A2_HUMAN (54-442): 5.65e-133: 393: 29.62