Protein: EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

Gene: EDEM2
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q9BV94

Gene Ontology (top 5):
GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 - calcium ion binding
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0005975 - carbohydrate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1245612

TXD11
Thioredoxin domain-containing protein 11

4

11

Small-scale

0.797

High

1415035

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

2

4

Small-scale

0.737

High

1200301

FBLN7
Fibulin-7

4

2

High-throughput

0.691

High

1415038

CHST8
Carbohydrate sulfotransferase 8

3

3

High-throughput

0.667

High

1415045

CC50A
Cell cycle control protein 50A

3

2

High-throughput

0.667

High

1407285

NOE1
Noelin

3

0

High-throughput

0.638

High

1316361

AGRG5
Adhesion G-protein coupled receptor G5

3

0

High-throughput

0.634

High

1415043

S38AA
Solute carrier family 38 member 10

3

0

High-throughput

0.634

High

969042

PRS8
26S proteasome regulatory subunit 8

2

1

High-throughput

0.628

High

1060291

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

1

High-throughput

0.628

High

1212725

TMTC4
Protein O-mannosyl-transferase TMTC4

2

1

High-throughput

0.628

High

452384

PDIA1
Protein disulfide-isomerase

1

11

Small-scale

0.618

High

1034813

NAAA
N-acylethanolamine-hydrolyzing acid amidase

2

2

High-throughput

0.611

High

71400

HECA2
HEPACAM family member 2

3

3

High-throughput

0.609

High

1347595

UHMK1
Serine/threonine-protein kinase Kist

3

1

High-throughput

0.604

High

1388581

OMA1
Metalloendopeptidase OMA1, mitochondrial

3

1

High-throughput

0.604

High

72878

HACD1
Very-long-chain

2

0

High-throughput

0.602

High

771548

TSP2
Thrombospondin-2

2

0

High-throughput

0.602

High

818835

TYRP2
L-dopachrome tautomerase

2

0

High-throughput

0.602

High

1241204

CC033
Protein C3orf33

2

0

High-throughput

0.602

High

1348049

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

2

0

High-throughput

0.602

High

229280

ANGL7
Angiopoietin-related protein 7

2

4

High-throughput

0.574

High

533748

CLUS
Clusterin

2

2

High-throughput

0.574

High

593612

GDC
Solute carrier family 25 member 16

2

1

High-throughput

0.574

High

1248793

LYZL1
Lysozyme-like protein 1

2

3

High-throughput

0.574

High

1260497

BRNP3
BMP/retinoic acid-inducible neural-specific protein 3

2

1

High-throughput

0.574

High

1286892

TM11B
Transmembrane protease serine 11B

2

7

High-throughput

0.574

High

1415036

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

2

1

High-throughput

0.574

High

699061

CALX
Calnexin

2

7

Small-scale

0.571

High

64382

CDHR4
Cadherin-related family member 4

1

3

High-throughput

0.536

High

388008

FIBG
Fibrinogen gamma chain

1

4

High-throughput

0.536

High

1030210

IL5RA
Interleukin-5 receptor subunit alpha

1

3

High-throughput

0.536

High

1105550

OS9
Protein OS-9

1

4

High-throughput

0.536

High

1187416

SHSL1
Protein shisa-like-1

1

1

High-throughput

0.536

High

1194708

GXLT1
Glucoside xylosyltransferase 1

1

1

High-throughput

0.536

High

1271325

CHST9
Carbohydrate sulfotransferase 9

1

3

High-throughput

0.536

High

1415044

SDF2L
Stromal cell-derived factor 2-like protein 1

1

1

High-throughput

0.536

High

1415048

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

4

High-throughput

0.536

High

1415049

DNJB9
DnaJ homolog subfamily B member 9

1

5

High-throughput

0.536

High

1415052

FBX2
F-box only protein 2

1

2

High-throughput

0.536

High

959939

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.518

High

1253792

QSOX2
Sulfhydryl oxidase 2

1

10

High-throughput

0.514

High

284413

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

High-throughput

0.513

High

424100

ITB2
Integrin beta-2

1

0

High-throughput

0.513

High

630347

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

0

High-throughput

0.513

High

880059

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.513

High

1111686

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.513

High

1311024

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.513

High

1415034

ABCA2
ATP-binding cassette sub-family A member 2

1

0

High-throughput

0.513

High

168449

NCTR3
Natural cytotoxicity triggering receptor 3

1

1

High-throughput

0.489

High

282862

CRLF1
Cytokine receptor-like factor 1

1

2

High-throughput

0.489

High

416645

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.489

High

455662

KLK3
Prostate-specific antigen

1

9

High-throughput

0.489

High

506902

CFC1
Cryptic protein

1

1

High-throughput

0.489

High

567971

PRG2
Bone marrow proteoglycan

1

3

High-throughput

0.489

High

731892

CEAM8
Cell adhesion molecule CEACAM8

1

3

High-throughput

0.489

High

1102956

ITAD
Integrin alpha-D

1

1

High-throughput

0.489

High

1231983

IL31
Interleukin-31

1

1

High-throughput

0.489

High

1308292

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.489

High

1333769

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.489

High

1363133

CLC2B
C-type lectin domain family 2 member B

1

4

High-throughput

0.489

High

1369057

GGH
Gamma-glutamyl hydrolase

1

1

High-throughput

0.489

High

1383454

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

2

High-throughput

0.489

High

1384592

ESPB1
Epididymal sperm-binding protein 1

1

4

High-throughput

0.489

High

1415039

KLK15
Kallikrein-15

1

5

High-throughput

0.489

High

1415041

TMPS5
Transmembrane protease serine 5

1

7

High-throughput

0.489

High

1415051

BTNL2
Butyrophilin-like protein 2

1

2

High-throughput

0.489

High

1415055

ANGP4
Angiopoietin-4

1

4

High-throughput

0.489

High

218711

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

1149263

SHH
Sonic hedgehog protein

1

2

Small-scale

0.479

High

1415050

SE1L1
Protein sel-1 homolog 1

1

4

Small-scale

0.479

High

1312595

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

71175

HIG1C
HIG1 domain family member 1C

1

1

High-throughput

0.445

High

170941

CLGN
Calmegin

1

7

High-throughput

0.445

High

1133852

KI2S5
Killer cell immunoglobulin-like receptor 2DS5

1

3

High-throughput

0.445

High

1362081

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

1

High-throughput

0.445

High

1381392

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

1

High-throughput

0.445

High

1395162

HIPL1
HHIP-like protein 1

1

2

High-throughput

0.445

High

1415037

LMA2L
VIP36-like protein

1

3

High-throughput

0.445

High

1415053

XCT
Cystine/glutamate transporter

1

2

High-throughput

0.445

High

1415057

ORNT1
Mitochondrial ornithine transporter 1

1

1

High-throughput

0.445

High

316559

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.426

High

941965

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.426

High

961565

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.426

High

1240582

MBOA5
Lysophospholipid acyltransferase 5

1

0

High-throughput

0.426

High

1358469

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.426

High

1415054

HIG1A
HIG1 domain family member 1A, mitochondrial

1

1

High-throughput

0.407

High

255530

CYTIP
Cytohesin-interacting protein

3

0

High-throughput

0.347

High

1160439

TAZ
Tafazzin

3

0

High-throughput

0.347

High

456977

CO8G
Complement component C8 gamma chain

2

0

High-throughput

0.328

High

1149622

SURF1
Surfeit locus protein 1

2

0

High-throughput

0.328

High

1248578

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

1337223

MCU
Calcium uniporter protein, mitochondrial

2

0

High-throughput

0.328

High

1353714

MOT10
Monocarboxylate transporter 10

2

0

High-throughput

0.328

High

1389722

TV23C
Golgi apparatus membrane protein TVP23 homolog C

2

0

High-throughput

0.328

High

1412344

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

2

0

High-throughput

0.328

High

1415029

MAD3
Max dimerization protein 3

2

0

High-throughput

0.328

High

1415047

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

2

0

High-throughput

0.328

High

248447

NMD3B
Glutamate receptor ionotropic, NMDA 3B

1

0

High-throughput

0.279

Low

332239

UCP5
Brain mitochondrial carrier protein 1

1

0

High-throughput

0.279

Low

426129

PPB1
Alkaline phosphatase, placental type

1

0

High-throughput

0.279

Low

570714

EDN3
Endothelin-3

1

0

High-throughput

0.279

Low

902887

BLK
Tyrosine-protein kinase Blk

1

0

High-throughput

0.279

Low

1287054

K1328
Protein hinderin

1

0

High-throughput

0.279

Low

1293659

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.279

Low

1322137

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low

1359740

HPSE2
Inactive heparanase-2

1

0

High-throughput

0.279

Low

1415031

SFXN3
Sideroflexin-3

1

0

High-throughput

0.279

Low

1415032

PRR14
Proline-rich protein 14

1

0

High-throughput

0.279

Low

1415046

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.279

Low

1415056

LIPG
Endothelial lipase

1

0

High-throughput

0.279

Low

568091

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

0

High-throughput

0.249

Low

1415040

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

0

Small-scale

0.249

Low

194850

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

0

High-throughput

0.232

Low

379571

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.232

Low

633430

ANPRB
Atrial natriuretic peptide receptor 2

1

0

High-throughput

0.232

Low

940588

ATP68
ATP synthase F(0) complex subunit j, mitochondrial

1

0

High-throughput

0.232

Low

1126286

GP176
G-protein coupled receptor 176

1

0

High-throughput

0.232

Low

1326570

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.232

Low

1414643

TCAB1
Telomerase Cajal body protein 1

1

0

High-throughput

0.232

Low

1415030

HIRP3
HIRA-interacting protein 3

1

0

High-throughput

0.232

Low

1415033

STRA6
Receptor for retinol uptake STRA6

1

0

High-throughput

0.232

Low

1415042

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025