HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: DHB4 (P51659)
Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]
Gene: HSD17B4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	32929329, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 736
+	Hs
		475499 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DHB4_HUMAN (1-736): 0: 910: 100.00
+	Hs
		227350 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DHRS2_HUMAN (7-247): 1.07e-73: 242: 24.31
+	Hs
		476449 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DECR2_HUMAN (4-254): 1.54e-71: 236: 20.68
+	At
		97042 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SDR4_ARATH (7-243): 2.79e-69: 231: 24.31
+	Hs
		475655 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KDSR_HUMAN (4-223): 6.1e-15: 78.6: 27.12