Protein: CDC20
Cell division cycle protein 20 homolog (p55CDC)

Gene: CDC20
Organism: Homo sapiens
Interactions: 231
UniProt ID: Q12834

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1086843

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

75

9

Small-scale

0.773

High

251747

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

68

20

Small-scale

0.773

High

718552

CDC27
Cell division cycle protein 27 homolog

62

20

Small-scale

0.772

High

573812

CCNB1
G2/mitotic-specific cyclin-B1

34

20

Small-scale

0.770

High

353810

PTTG1
Securin

28

1

Small-scale

0.769

High

629109

CCNA2
Cyclin-A2

20

20

Small-scale

0.767

High

1086933

APC4
Anaphase-promoting complex subunit 4

26

7

Small-scale

0.766

High

1086841

CDC16
Cell division cycle protein 16 homolog

14

20

Small-scale

0.759

High

224110

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

12

17

Small-scale

0.758

High

1086934

ANC2
Anaphase-promoting complex subunit 2

14

20

Small-scale

0.758

High

224272

BUB3
Mitotic checkpoint protein BUB3

14

20

Small-scale

0.758

High

1086931

APC7
Anaphase-promoting complex subunit 7

13

20

Small-scale

0.754

High

1086930

CDC23
Cell division cycle protein 23 homolog

11

20

Small-scale

0.753

High

1086905

APC1
Anaphase-promoting complex subunit 1

10

10

Small-scale

0.747

High

667813

CDK2
Cyclin-dependent kinase 2

7

18

Small-scale

0.745

High

1086891

APC16
Anaphase-promoting complex subunit 16

7

1

Small-scale

0.745

High

1086844

SKP2
S-phase kinase-associated protein 2

7

5

Small-scale

0.742

High

1086840

CDC20
Cell division cycle protein 20 homolog

7

17

Small-scale

0.741

High

1086932

APC5
Anaphase-promoting complex subunit 5

7

6

Small-scale

0.737

High

1086936

FZR1
Fizzy-related protein homolog

6

19

Small-scale

0.730

High

808042

CDN1A
Cyclin-dependent kinase inhibitor 1

6

4

Small-scale

0.729

High

1086853

MD2BP
MAD2L1-binding protein

11

0

Small-scale

0.723

High

1086882

CDC26
Anaphase-promoting complex subunit CDC26

6

1

Small-scale

0.722

High

1086937

APC10
Anaphase-promoting complex subunit 10

6

10

Small-scale

0.717

High

919918

PLK1
Serine/threonine-protein kinase PLK1

5

12

Small-scale

0.714

High

881892

TCPG
T-complex protein 1 subunit gamma

5

20

Small-scale

0.714

High

1086898

TCPH
T-complex protein 1 subunit eta

5

20

Small-scale

0.714

High

875930

TCPE
T-complex protein 1 subunit epsilon

5

20

Small-scale

0.711

High

443338

CDK1
Cyclin-dependent kinase 1

4

17

Small-scale

0.694

High

1086859

UBE2S
Ubiquitin-conjugating enzyme E2 S

4

14

Small-scale

0.694

High

956655

CKS1
Cyclin-dependent kinases regulatory subunit 1

4

6

Small-scale

0.691

High

144174

UBE2C
Ubiquitin-conjugating enzyme E2 C

4

12

Small-scale

0.688

High

507887

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

10

Small-scale

0.688

High

1006991

TCPB
T-complex protein 1 subunit beta

4

20

Small-scale

0.686

High

908819

NEK2
Serine/threonine-protein kinase Nek2

4

8

Small-scale

0.683

High

1086919

APC11
Anaphase-promoting complex subunit 11

4

5

Small-scale

0.683

High

1086928

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

3

9

Small-scale

0.675

High

1086917

RASF1
Ras association domain-containing protein 1

3

7

Small-scale

0.670

High

948521

APC15
Anaphase-promoting complex subunit 15

3

1

Small-scale

0.667

High

1067235

EP300
Histone acetyltransferase p300

3

17

Small-scale

0.667

High

1007630

CCNA1
Cyclin-A1

3

20

Small-scale

0.665

High

1086944

SYYM
Tyrosine--tRNA ligase, mitochondrial

4

0

High-throughput

0.664

High

325811

UBR5
E3 ubiquitin-protein ligase UBR5

3

12

Small-scale

0.664

High

1086935

FBX5
F-box only protein 5

3

6

Small-scale

0.664

High

284307

GEMI
Geminin

3

2

Small-scale

0.646

High

241527

PRKN
E3 ubiquitin-protein ligase parkin

3

15

Small-scale

0.640

High

610635

TCPA
T-complex protein 1 subunit alpha

3

20

Small-scale

0.640

High

821323

TCPZ
T-complex protein 1 subunit zeta

3

20

Small-scale

0.640

High

899011

TCPQ
T-complex protein 1 subunit theta

3

20

Small-scale

0.640

High

899362

TCPD
T-complex protein 1 subunit delta

3

20

Small-scale

0.640

High

1045225

TF65
Transcription factor p65

2

5

Small-scale

0.634

High

239048

ZNRD2
Protein ZNRD2

2

1

High-throughput

0.628

High

562592

RINI
Ribonuclease inhibitor

2

1

High-throughput

0.628

High

1086948

PCDC2
Protocadherin alpha-C2

2

2

High-throughput

0.628

High

227523

SPOP
Speckle-type POZ protein

2

5

Small-scale

0.624

High

994192

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

7

Small-scale

0.624

High

1026342

HSF1
Heat shock factor protein 1

2

6

Small-scale

0.624

High

1086852

MDC1
Mediator of DNA damage checkpoint protein 1

2

20

Small-scale

0.624

High

1086912

EGLN3
Prolyl hydroxylase EGLN3

2

2

Small-scale

0.624

High

170108

AURKA
Aurora kinase A

2

10

Small-scale

0.611

High

1086939

PHF8
Histone lysine demethylase PHF8

2

8

Small-scale

0.611

High

422009

A4
Amyloid-beta precursor protein

2

6

High-throughput

0.602

High

1086890

DCPS
m7GpppX diphosphatase

2

1

Small-scale

0.602

High

345725

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

16

Small-scale

0.584

High

371887

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

896191

MXI1
Max-interacting protein 1

2

16

Small-scale

0.584

High

1029069

E2F1
Transcription factor E2F1

2

4

Small-scale

0.584

High

1086855

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

2

2

Small-scale

0.584

High

1086861

FBX43
F-box only protein 43

2

6

Small-scale

0.584

High

1086886

CBP
CREB-binding protein

2

15

Small-scale

0.584

High

1086949

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

2

18

Small-scale

0.584

High

1086908

P63
Tumor protein 63

1

8

Small-scale

0.578

High

1086872

SPERI
Speriolin

1

5

Small-scale

0.573

High

1086878

SH2D3
SH2 domain-containing protein 3C

2

5

High-throughput

0.571

High

541016

PIM1
Serine/threonine-protein kinase pim-1

1

9

Small-scale

0.561

High

1044339

HSF2
Heat shock factor protein 2

1

6

Small-scale

0.561

High

1060253

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

3

Small-scale

0.561

High

1086866

OTU7B
OTU domain-containing protein 7B

1

6

Small-scale

0.561

High

1086876

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

8

Small-scale

0.561

High

1086927

TBK1
Serine/threonine-protein kinase TBK1

1

11

Small-scale

0.561

High

186739

P73
Tumor protein p73

1

8

Small-scale

0.536

High

258852

DNJA2
DnaJ homolog subfamily A member 2

1

13

High-throughput

0.536

High

753917

CKS2
Cyclin-dependent kinases regulatory subunit 2

1

6

High-throughput

0.536

High

1036644

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

3

High-throughput

0.536

High

1086846

HDAC1
Histone deacetylase 1

1

15

Small-scale

0.536

High

1086873

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.536

High

1086885

HDAC2
Histone deacetylase 2

1

15

Small-scale

0.536

High

1086887

CSN5
COP9 signalosome complex subunit 5

1

10

High-throughput

0.536

High

1086896

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.536

High

1086918

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

7

High-throughput

0.536

High

1086947

MB212
Protein mab-21-like 2

1

1

High-throughput

0.536

High

300265

KT33A
Keratin, type I cuticular Ha3-I

1

17

High-throughput

0.515

High

1007511

KRT85
Keratin, type II cuticular Hb5

1

9

High-throughput

0.515

High

1057129

PRDX1
Peroxiredoxin-1

1

8

High-throughput

0.515

High

1086851

K1H2
Keratin, type I cuticular Ha2

1

17

High-throughput

0.515

High

1086856

K1H1
Keratin, type I cuticular Ha1

1

17

High-throughput

0.515

High

1086902

KRA93
Keratin-associated protein 9-3

1

1

High-throughput

0.515

High

1086903

KRA92
Keratin-associated protein 9-2

1

1

High-throughput

0.515

High

1086943

AXIN2
Axin-2

1

3

Small-scale

0.515

High

1086914

RDH14
Retinol dehydrogenase 14

1

0

High-throughput

0.513

High

405445

KITH
Thymidine kinase, cytosolic

1

2

Small-scale

0.501

High

663358

KTHY
Thymidylate kinase

1

1

Small-scale

0.501

High

754822

H2B1B
Histone H2B type 1-B

1

9

Small-scale

0.501

High

854020

KI67
Proliferation marker protein Ki-67

1

14

Small-scale

0.501

High

998256

H31
Histone H3.1

1

10

Small-scale

0.501

High

1086842

FADD
FAS-associated death domain protein

1

1

Small-scale

0.501

High

1086857

PCH2
Pachytene checkpoint protein 2 homolog

1

18

Small-scale

0.501

High

1086883

KI18A
Kinesin-like protein KIF18A

1

5

Small-scale

0.501

High

1086897

CDC6
Cell division control protein 6 homolog

1

5

Small-scale

0.501

High

1086907

CDT1
DNA replication factor Cdt1

1

1

Small-scale

0.501

High

1086860

KR195
Keratin-associated protein 19-5

1

0

High-throughput

0.493

High

1086921

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.493

High

122944

SGK1
Serine/threonine-protein kinase Sgk1

1

10

High-throughput

0.479

High

172752

XPO1
Exportin-1

1

16

High-throughput

0.479

High

221254

DCX
Neuronal migration protein doublecortin

1

1

Small-scale

0.479

High

341561

EYA4
Protein phosphatase EYA4

1

16

High-throughput

0.479

High

376817

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

4

High-throughput

0.479

High

400732

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.479

High

412956

CPNS1
Calpain small subunit 1

1

3

High-throughput

0.479

High

413724

P53
Cellular tumor antigen p53

1

8

High-throughput

0.479

High

457395

TBB5
Tubulin beta chain

1

20

High-throughput

0.479

High

507176

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

10

High-throughput

0.479

High

519496

MYBB
Myb-related protein B

1

9

Small-scale

0.479

High

532549

CH60
60 kDa heat shock protein, mitochondrial

1

13

High-throughput

0.479

High

534991

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

537060

HSP7C
Heat shock cognate 71 kDa protein

1

17

High-throughput

0.479

High

541455

FGFR1
Fibroblast growth factor receptor 1

1

12

High-throughput

0.479

High

551015

PCNA
Proliferating cell nuclear antigen

1

1

Small-scale

0.479

High

588564

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

655808

TBG1
Tubulin gamma-1 chain

1

20

Small-scale

0.479

High

658137

RS3
Small ribosomal subunit protein uS3

1

7

High-throughput

0.479

High

695319

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

717784

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

11

Small-scale

0.479

High

719135

MPIP1
M-phase inducer phosphatase 1

1

2

High-throughput

0.479

High

719216

MPIP2
M-phase inducer phosphatase 2

1

2

High-throughput

0.479

High

755549

TTK
Dual specificity protein kinase TTK

1

10

Small-scale

0.479

High

761377

HS71L
Heat shock 70 kDa protein 1-like

1

17

High-throughput

0.479

High

768059

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

771586

HXD13
Homeobox protein Hox-D13

1

3

Small-scale

0.479

High

830638

CCNF
Cyclin-F

1

20

Small-scale

0.479

High

832307

ID1
DNA-binding protein inhibitor ID-1

1

6

Small-scale

0.479

High

857321

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

4

Small-scale

0.479

High

862080

YAP1
Transcriptional coactivator YAP1

1

10

High-throughput

0.479

High

877324

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

Small-scale

0.479

High

886472

CTCF
Transcriptional repressor CTCF

1

3

Small-scale

0.479

High

897773

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.479

High

912855

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

20

High-throughput

0.479

High

915950

NUP98
Nuclear pore complex protein Nup98-Nup96

1

6

Small-scale

0.479

High

925648

IST1
IST1 homolog

1

1

Small-scale

0.479

High

964896

WDR5
WD repeat-containing protein 5

1

18

Small-scale

0.479

High

966251

1433G
14-3-3 protein gamma

1

18

High-throughput

0.479

High

972377

RS14
Small ribosomal subunit protein uS11

1

7

Small-scale

0.479

High

977472

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

7

Small-scale

0.479

High

981804

RL23
Large ribosomal subunit protein uL14

1

6

High-throughput

0.479

High

994497

YBOX1
Y-box-binding protein 1

1

7

Small-scale

0.479

High

996923

TBA4A
Tubulin alpha-4A chain

1

18

High-throughput

0.479

High

997302

TBB4B
Tubulin beta-4B chain

1

20

High-throughput

0.479

High

1004498

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1027411

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

15

Small-scale

0.479

High

1029814

RUNX1
Runt-related transcription factor 1

1

4

Small-scale

0.479

High

1040485

HHEX
Hematopoietically-expressed homeobox protein HHEX

1

4

Small-scale

0.479

High

1041503

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

Small-scale

0.479

High

1049240

1433F
14-3-3 protein eta

1

18

High-throughput

0.479

High

1085531

FOXO1
Forkhead box protein O1

1

10

Small-scale

0.479

High

1086845

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.479

High

1086847

CUL1
Cullin-1

1

20

Small-scale

0.479

High

1086848

CUL3
Cullin-3

1

20

Small-scale

0.479

High

1086850

TFDP1
Transcription factor Dp-1

1

2

Small-scale

0.479

High

1086854

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.479

High

1086858

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

2

Small-scale

0.479

High

1086863

DAB2P
Disabled homolog 2-interacting protein

1

6

Small-scale

0.479

High

1086864

FBX31
F-box only protein 31

1

1

Small-scale

0.479

High

1086867

FBX42
F-box only protein 42

1

5

High-throughput

0.479

High

1086869

CE128
Centrosomal protein of 128 kDa

1

20

High-throughput

0.479

High

1086870

PAXI1
PAX-interacting protein 1

1

14

High-throughput

0.479

High

1086871

TBA1A
Tubulin alpha-1A chain

1

20

High-throughput

0.479

High

1086874

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

6

Small-scale

0.479

High

1086875

PB1
Protein polybromo-1

1

13

High-throughput

0.479

High

1086879

SIR6
NAD-dependent protein deacylase sirtuin-6

1

8

High-throughput

0.479

High

1086881

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

4

Small-scale

0.479

High

1086888

RNF34
E3 ubiquitin-protein ligase RNF34

1

5

Small-scale

0.479

High

1086889

FBXW5
F-box/WD repeat-containing protein 5

1

1

Small-scale

0.479

High

1086892

CHFR
E3 ubiquitin-protein ligase CHFR

1

10

Small-scale

0.479

High

1086893

AURKB
Aurora kinase B

1

9

Small-scale

0.479

High

1086894

DDRGK
DDRGK domain-containing protein 1

1

3

Small-scale

0.479

High

1086895

MAML3
Mastermind-like protein 3

1

12

High-throughput

0.479

High

1086899

TBA1C
Tubulin alpha-1C chain

1

20

High-throughput

0.479

High

1086904

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

20

High-throughput

0.479

High

1086910

CUED2
CUE domain-containing protein 2

1

1

Small-scale

0.479

High

1086913

CLSPN
Claspin

1

8

Small-scale

0.479

High

1086915

MOV10
Helicase MOV-10

1

8

High-throughput

0.479

High

1086916

ANLN
Anillin

1

5

High-throughput

0.479

High

1086922

HECW2
E3 ubiquitin-protein ligase HECW2

1

7

High-throughput

0.479

High

1086923

HDAC6
Protein deacetylase HDAC6

1

20

Small-scale

0.479

High

1086924

DAXX
Death domain-associated protein 6

1

1

Small-scale

0.479

High

1086925

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1086926

KDM5B
Lysine-specific demethylase 5B

1

8

Small-scale

0.479

High

1086938

TRI33
E3 ubiquitin-protein ligase TRIM33

1

18

Small-scale

0.479

High

1086940

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

6

Small-scale

0.479

High

1086941

FBW1A
F-box/WD repeat-containing protein 1A

1

19

Small-scale

0.479

High

1086942

NINL
Ninein-like protein

1

18

Small-scale

0.479

High

1086945

TRRAP
Transformation/transcription domain-associated protein

1

10

Small-scale

0.479

High

329919

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

Small-scale

0.458

High

1086862

FRY
Protein furry homolog

1

0

High-throughput

0.458

High

1086880

BANP
Protein BANP

1

0

Small-scale

0.458

High

1033351

CDR2
Cerebellar degeneration-related protein 2

1

1

Small-scale

0.457

High

704952

RBL1
Retinoblastoma-like protein 1

1

3

High-throughput

0.445

High

786080

LONM
Lon protease homolog, mitochondrial

1

6

High-throughput

0.445

High

1086865

A16L1
Autophagy-related protein 16-1

1

18

High-throughput

0.445

High

1086900

APC13
Anaphase-promoting complex subunit 13

1

1

High-throughput

0.445

High

49939

LNP1
Leukemia NUP98 fusion partner 1

1

1

Small-scale

0.437

High

212394

SPIT2
Kunitz-type protease inhibitor 2

1

4

High-throughput

0.437

High

276394

CILP1
Cartilage intermediate layer protein 1

1

1

High-throughput

0.437

High

293631

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

801287

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.437

High

1061333

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

4

Small-scale

0.437

High

1064418

DSC1
Desmocollin-1

1

3

High-throughput

0.437

High

1086849

TBB2A
Tubulin beta-2A chain

1

20

High-throughput

0.437

High

1086868

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

1086877

RAVR1
Ribonucleoprotein PTB-binding 1

1

15

High-throughput

0.437

High

1086884

PKHO2
Pleckstrin homology domain-containing family O member 2

1

6

High-throughput

0.437

High

1086901

EIF2A
Eukaryotic translation initiation factor 2A

1

19

High-throughput

0.437

High

1086906

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

11

High-throughput

0.437

High

1086909

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.437

High

1086911

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

1086920

T2R13
Taste receptor type 2 member 13

1

1

Small-scale

0.437

High

1086929

XPO7
Exportin-7

1

11

High-throughput

0.437

High

124322

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

1086946

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low

261948

RNH1
Ribonuclease H1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025