HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: DHSO (Q00796)
Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) ((R,R)-butanediol dehydrogenase) (EC 1.1.1.4) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Ribitol dehydrogenase) (RDH) (EC 1.1.1.56) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9)
Gene: SORD

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008270 - zinc ion binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 357
+	Hs
		226373 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ADHX_HUMAN (1-350): 7.97e-112: 332: 18.78
+	Sc
		423559 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		ADH3_YEAST (2-349): 7.41e-98: 296: 24.01
+	Hs
		475637 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DHSO_HUMAN (1-357): 2.23e-125: 366: 100.00
+	Sc
		333666 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		ADH1_YEAST (3-349): 1.31e-91: 279: 22.95
+	At
		1092034 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DHSO_ARATH (2-350): 1.19e-113: 336: 44.63
+	At
		1091952 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ADHX_ARATH (3-349): 5.38e-109: 325: 18.62
+	Hs
		475437 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ADH7_HUMAN (2-350): 1.37e-102: 309: 19.95
+	At
		1091846 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		ADHL4_ARATH (3-350): 2.67e-96: 292: 18.73
+	At
		1091893 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q93ZM6_ARATH (8-350): 1.54e-90: 279: 20.16
+	Sc
		477287 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		BDH1_YEAST (18-232): 1.99e-24: 104: 32.51