HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TRAP1 (Q12931)
Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)
Gene: TRAP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0019901 - protein kinase binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 704
+	Hs
		226418 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ENPL_HUMAN (10-702): 0: 880: 29.24
+	Hs
		312594 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		TRAP1_HUMAN (1-704): 0: 927: 100.00
+	Hs
		475683 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TRAP1_HUMAN (1-704): 0: 927: 100.00
+	At
		850795 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		HS903_ARATH (83-701): 0: 885: 30.63
+	At
		878277 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		HS902_ARATH (83-701): 0: 885: 30.63
+	At
		646587 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		HS901_ARATH (83-701): 0: 883: 30.29
+	At
		137803 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		HS904_ARATH (83-701): 0: 882: 30.63
+	Sc
		477100 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		HSC82_YEAST (84-702): 0: 791: 31.05
+	Sc
		365633 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		HSP82_YEAST (84-287): 1.22e-42: 166: 45.28
+	Pf
		1181544 Q7KQK2_PLAF7 (1-76): 8.17e-31: 124: 28.95		Q8III6_PLAF7 (88-287): 1.1e-50: 192: 45.15