HitPredict

Interactor 1: SPOP (O43791)
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Gene: SPOP

Interactor 2: RXRB (P28702)
Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)
Gene: RXRB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.669

Property	Details
Experiments	31911863, 16189514, 21988832
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 374 Hs			1 533
+	Hs
		704537 SPOPL_HUMAN (1-374): 5.81e-120: 354: 80.61		RXRB_HUMAN (1-533): 3.87e-146: 432: 100.00
+	Mm
		1222846 SPOP_MOUSE (1-374): 2.72e-128: 374: 100.00		ERR2_MOUSE (97-529): 5.85e-102: 315: 27.79
+	Hs
		227297 SPOP_HUMAN (1-374): 2.72e-128: 374: 100.00		ESR1_HUMAN (54-532): 4.59e-92: 294: 25.48
+	Hs
		652512 KEAP1_HUMAN (132-363): 1.22e-55: 194: 22.36		NR4A1_HUMAN (54-526): 5.12e-88: 284: 27.42
+	Hs
		1199009 KLH12_HUMAN (168-373): 5.95e-61: 207: 21.85		ESR2_HUMAN (186-528): 8.09e-44: 164: 32.89
+	Hs
		1121481 KEAP1_HUMAN (132-363): 1.22e-55: 194: 22.36		ESR2_HUMAN (186-528): 8.09e-44: 164: 32.89