HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: DPYL3 (Q14195)
Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1)
Gene: DPYSL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0017124 - SH3 domain binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 570
+	Hs
		227582 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DPYL2_HUMAN (1-569): 0: 742: 76.71
+	Hs
		228494 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DPYL5_HUMAN (9-565): 0: 649: 50.71
+	Hs
		1219362 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		DPYL5_HUMAN (9-565): 0: 649: 50.71
+	Hs
		226587 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PYR1_HUMAN (26-562): 1.21e-133: 431: 17.65
+	At
		1092058 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DPYS_ARATH (12-489): 0: 555: 43.93
+	Sc
		424289 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PYR1_YEAST (25-529): 5.54e-78: 270: 15.32