HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: UBP39 (Q53GS9)
Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein)
Gene: USP39

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UCH~ubiquitin, ubiquitin~zf-UBP
Common GO terms	GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 565
+	Hs
		228270 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBP7_HUMAN (10-557): 4.92e-116: 371: 14.06
+	Hs
		226067 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBP2_HUMAN (180-560): 5.95e-109: 340: 21.83
+	Hs
		226736 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBP8_HUMAN (177-564): 2.41e-101: 332: 19.80
+	Hs
		1121221 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		UBP39_HUMAN (1-565): 2.92e-163: 478: 100.00
+	Hs
		226777 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBP5_HUMAN (13-493): 7.35e-87: 288: 15.81
+	Hs
		1273850 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		UBP7_HUMAN (10-557): 4.92e-116: 371: 14.06
+	Hs
		228159 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBP33_HUMAN (411-564): 3.53e-45: 173: 26.54
+	Hs
		475123 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		UBP7_HUMAN (10-557): 4.92e-116: 371: 14.06
+	Hs
		271185 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		UBP2_HUMAN (180-560): 5.95e-109: 340: 21.83
+	Hs
		1168542 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		UBP22_HUMAN (123-560): 1.99e-114: 351: 17.39
+	Hs
		271114 Q5U5U6_HUMAN (1-234): 1.14e-59: 197: 17.92		UBP2_HUMAN (180-560): 5.95e-109: 340: 21.83
+	Sc
		477366 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		UBP8_YEAST (80-552): 2.01e-107: 331: 16.80
+	Hs
		1317098 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		UBP21_HUMAN (223-560): 2.89e-97: 308: 18.85
+	Hs
		905386 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		UBP46_HUMAN (201-556): 1.61e-90: 284: 19.31
+	Hs
		259291 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		UBP12_HUMAN (209-556): 5.21e-90: 283: 18.92
+	Hs
		474951 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		UBP5_HUMAN (13-493): 7.35e-87: 288: 15.81
+	Hs
		474982 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		UBP46_HUMAN (201-556): 1.61e-90: 284: 19.31
+	Hs
		64200 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP27_HUMAN (190-563): 1.93e-98: 307: 16.83
+	Hs
		259261 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBP12_HUMAN (209-556): 5.21e-90: 283: 18.92
+	Hs
		1024362 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		UBP4_HUMAN (222-340): 1.69e-10: 65.9: 33.33