Protein: MYD88
Myeloid differentiation primary response protein MyD88

Gene: MYD88
Organism: Mus musculus
Interactions: 67
UniProt ID: P22366

Gene Ontology (top 5):
GO:0002238 - response to molecule of fungal origin
GO:0002269 - leukocyte activation involved in inflammatory response
GO:0002283 - neutrophil activation involved in immune response
GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0005121 - Toll binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

648059

IRAK1
Interleukin-1 receptor-associated kinase 1

9

20

Small-scale

0.968

High

648032

MYD88
Myeloid differentiation primary response protein MyD88

3

20

Small-scale

0.850

High

648066

IRAK2
Interleukin-1 receptor-associated kinase-like 2

3

20

Small-scale

0.827

High

648082

TLR4
Toll-like receptor 4

15

20

Small-scale

0.759

High

648076

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

2

6

Small-scale

0.754

High

648043

TRAF6
TNF receptor-associated factor 6

8

19

Small-scale

0.746

High

648071

IRAK4
Interleukin-1 receptor-associated kinase 4

6

20

Small-scale

0.728

High

148435

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

Small-scale

0.724

High

648054

TRAF3
TNF receptor-associated factor 3

3

18

Small-scale

0.670

High

562914

IL1R1
Interleukin-1 receptor type 1

3

13

Small-scale

0.650

High

583127

IRF1
Interferon regulatory factor 1

3

20

Small-scale

0.650

High

648037

IRF5
Interferon regulatory factor 5

3

20

Small-scale

0.650

High

648045

IRF7
Interferon regulatory factor 7

3

20

Small-scale

0.640

High

648083

TLR2
Toll-like receptor 2

3

20

Small-scale

0.640

High

648050

CBLB
E3 ubiquitin-protein ligase CBL-B

2

2

Small-scale

0.621

High

648055

FADD
FAS-associated death domain protein

1

7

Small-scale

0.618

High

648085

TNIP1
TNFAIP3-interacting protein 1

2

2

Small-scale

0.611

High

648078

TLR9
Toll-like receptor 9

2

20

Small-scale

0.586

High

648081

FLII
Protein flightless-1 homolog

2

1

Small-scale

0.584

High

648070

IRAK3
Interleukin-1 receptor-associated kinase 3

1

20

Small-scale

0.575

High

648035

BTK
Tyrosine-protein kinase BTK

1

15

Small-scale

0.536

High

648036

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.536

High

648079

TR13B
Tumor necrosis factor receptor superfamily member 13B

1

1

Small-scale

0.536

High

648063

RNF41
E3 ubiquitin-protein ligase NRDP1

1

18

Small-scale

0.528

High

312651

BECN1
Beclin-1

1

1

Small-scale

0.515

High

648048

TF65
Transcription factor p65

1

1

Small-scale

0.515

High

648057

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

4

Small-scale

0.515

High

648060

IRF4
Interferon regulatory factor 4

1

20

Small-scale

0.515

High

648077

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

6

Small-scale

0.515

High

522148

BCL2
Apoptosis regulator Bcl-2

1

0

Small-scale

0.493

High

508956

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

1

2

Small-scale

0.479

High

627453

BIP
Endoplasmic reticulum chaperone BiP

1

7

Small-scale

0.479

High

648033

IRF2
Interferon regulatory factor 2

1

20

Small-scale

0.479

High

648034

FAK1
Focal adhesion kinase 1

1

14

Small-scale

0.479

High

648038

ARL1
ADP-ribosylation factor-like protein 1

1

2

Small-scale

0.479

High

648039

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.479

High

648042

TBA1C
Tubulin alpha-1C chain

1

6

Small-scale

0.479

High

648047

TBB5
Tubulin beta-5 chain

1

7

Small-scale

0.479

High

648049

EPS8
Epidermal growth factor receptor kinase substrate 8

1

11

Small-scale

0.479

High

648051

LRRF1
Leucine-rich repeat flightless-interacting protein 1

1

3

Small-scale

0.479

High

648053

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

Small-scale

0.479

High

648056

IL1AP
Interleukin-1 receptor accessory protein

1

20

Small-scale

0.479

High

648061

SQSTM
Sequestosome-1

1

2

Small-scale

0.479

High

648062

SPOP
Speckle-type POZ protein

1

6

Small-scale

0.479

High

648068

I17RD
Interleukin-17 receptor D

1

2

Small-scale

0.479

High

648069

MTA1
Metastasis-associated protein MTA1

1

1

Small-scale

0.479

High

648072

STK38
Serine/threonine-protein kinase 38

1

2

Small-scale

0.479

High

648073

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

3

Small-scale

0.479

High

648084

TBK1
Serine/threonine-protein kinase TBK1

1

6

Small-scale

0.479

High

648086

HDAC6
Protein deacetylase HDAC6

1

1

Small-scale

0.479

High

582211

INGR1
Interferon gamma receptor 1

1

0

Small-scale

0.458

High

648044

TANK
TRAF family member-associated NF-kappa-B activator

1

0

Small-scale

0.458

High

648046

NXN
Nucleoredoxin

1

0

Small-scale

0.458

High

648065

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

Small-scale

0.458

High

648067

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.458

High

648075

TNIP2
TNFAIP3-interacting protein 2

1

0

Small-scale

0.458

High

205657

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1

4

Small-scale

0.445

High

648058

RAGE
Advanced glycosylation end product-specific receptor

1

6

Small-scale

0.445

High

648040

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.438

High

648041

TBB4B
Tubulin beta-4B chain

1

7

Small-scale

0.437

High

648080

TMOD3
Tropomodulin-3

1

1

Small-scale

0.437

High

450382

CSF1
Macrophage colony-stimulating factor 1

1

0

Small-scale

0.426

High

648052

IASPP
RelA-associated inhibitor

1

0

Small-scale

0.426

High

648074

LRC59
Leucine-rich repeat-containing protein 59 [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed]

1

3

High-throughput

0.417

High

108253

G3X8V5
ORC ubiquitin ligase 1

1

0

Small-scale

0.249

Low

648064

Q8BIS2
IF rod domain-containing protein

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025