HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: DDI2 (Q5TDH0)
Protein DDI1 homolog 2 (EC 3.4.23.-)
Gene: DDI2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~ubiquitin, ubiquitin~zf-RING_12, ubiquitin~zf-RING_14
Common GO terms	GO:0005829 - cytosol GO:0010498 - proteasomal protein catabolic process GO:0031647 - regulation of protein stability GO:0043130 - ubiquitin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 399
+	Hs
		475888 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DDI2_HUMAN (1-399): 1.67e-162: 463: 100.00
+	Hs
		229056 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80
+	Hs
		476101 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DDI1_HUMAN (1-392): 7.44e-148: 426: 70.75
+	Hs
		226785 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		BAG6_HUMAN (4-173): 4.8e-28: 118: 15.08
+	Hs
		226969 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RD23A_HUMAN (3-198): 2.36e-28: 116: 15.00
+	Sc
		477305 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		DDI1_YEAST (3-395): 7.99e-93: 287: 30.92
+	Hs
		227107 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RS27A_HUMAN (10-77): 3.2e-14: 71.7: 22.06
+	Hs
		1137416 Q5U5U6_HUMAN (1-234): 1.14e-59: 197: 17.92		UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80
+	Hs
		475241 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80
+	Hs
		475223 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20
+	Hs
		1286323 Q96C32_HUMAN (1-153): 4.21e-49: 172: 19.48		UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80
+	Xl
		1186353 Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33		Q9PVN8_XENLA (31-241): 2.49e-40: 152: 14.46
+	Sc
		477360 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		DSK2_YEAST (19-213): 6.83e-31: 123: 15.49
+	Sc
		477189 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RAD23_YEAST (5-202): 3.88e-26: 110: 16.00
+	Hs
		476565 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80
+	Hs
		476525 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20
+	Hs
		476438 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		UBQL4_HUMAN (8-241): 1.8e-44: 164: 14.59
+	Dm
		1362837 Q9W418_DROME (1-77): 5.42e-30: 124: 32.47		Q9VCD5_DROME (5-227): 2.18e-35: 133: 12.88
+	Hs
		475525 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RD23A_HUMAN (3-198): 2.36e-28: 116: 15.00
+	Hs
		475590 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RS27A_HUMAN (10-77): 3.2e-14: 71.7: 22.06