HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: LIMA1 (Q9UHB6)
LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)
Gene: LIMA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35987950, 35256949
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 759
+	Hs
		476522 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		227885 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MICA3_HUMAN (271-544): 5.7e-43: 170: 23.93
+	Hs
		227577 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CSRP2_HUMAN (254-450): 3.35e-41: 151: 18.27
+	Hs
		226512 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CSRP1_HUMAN (254-449): 3.7e-34: 131: 15.82
+	Hs
		150494 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ABLM1_HUMAN (298-548): 8.97e-23: 106: 11.28
+	Hs
		226828 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAXI_HUMAN (268-446): 5.9e-14: 77.3: 14.53
+	Hs
		227474 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LASP1_HUMAN (390-480): 2.66e-11: 66.8: 25.00
+	At
		473452 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DA1_ARATH (258-663): 6.44e-71: 243: 11.64
+	At
		1091861 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DAR1_ARATH (352-620): 2.29e-59: 212: 12.46
+	At
		1013088 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		DAR2_ARATH (361-620): 2.64e-54: 197: 12.22
+	At
		1092228 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		WLI2B_ARATH (383-511): 2.95e-43: 156: 29.46
+	Hs
		475825 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CSRP2_HUMAN (254-450): 3.35e-41: 151: 18.27
+	Xl
		1186352 Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33		Q9DDK9_XENLA (268-446): 6.19e-15: 80.4: 14.53
+	At
		1091936 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		WLIM1_ARATH (382-516): 2.48e-33: 128: 28.99