Interactor 1: IDH3B (O43837)
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta)
Gene: IDH3B
Interactor 2: IDH3A (P50213)
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)
Gene: IDH3A
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.89 | 1.00 | 0.947 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 37071682, 26186194, 28514442, 33961781, 31839598, 31515270 |
| Identification Methods | cross-linking study, affinity chromatography technology, anti tag coimmunoprecipitation, x-ray crystallography, molecular sieving |
| Interaction Type | physical association, association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Iso_dh~Iso_dh |
| Common GO terms | GO:0000287 - magnesium ion binding GO:0004449 - isocitrate dehydrogenase (NAD+) activity GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix and 4 others more... |
| Homologous interactions | 15 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
