HitPredict

Interactor 1: TRAK2 (O60296)
Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein)
Gene: TRAK2

Interactor 2: AAPK1 (Q13131)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: PRKAA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030425 - dendrite
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 914 Hs			1 559
+	Rn
		871291 MYH9_RAT (2-607): 7.66e-21: 101: 9.94		AAPK1_RAT (1-559): 0: 593: 99.11
+	Rn
		655925 DCTN1_RAT (11-396): 1.76e-17: 90: 16.15		AAPK1_RAT (1-559): 0: 593: 99.11
+	Rn
		871335 MYH10_RAT (1-356): 6.79e-13: 75.3: 9.39		AAPK1_RAT (1-559): 0: 593: 99.11
+	Hs
		1051339 DCTN1_HUMAN (101-551): 8.67e-12: 71.5: 14.47		MARK2_HUMAN (10-545): 5.04e-150: 451: 29.64
+	Hs
		725223 MYH10_HUMAN (6-460): 3.06e-13: 76.5: 10.24		MARK4_HUMAN (18-543): 9.01e-140: 424: 28.76
+	Hs
		1268074 MY18A_HUMAN (253-615): 2.48e-12: 73.3: 9.14		MARK4_HUMAN (18-543): 9.01e-140: 424: 28.76
+	Hs
		724967 MYH9_HUMAN (10-470): 8.16e-10: 65.3: 9.07		MARK4_HUMAN (18-543): 9.01e-140: 424: 28.76
+	Hs
		728513 MYH11_HUMAN (1-398): 5.32e-16: 85.3: 9.65		SIK2_HUMAN (10-340): 1.75e-85: 286: 42.69
+	Hs
		725242 MYH10_HUMAN (6-460): 3.06e-13: 76.5: 10.24		SIK2_HUMAN (10-340): 1.75e-85: 286: 42.69
+	Hs
		725010 MYH9_HUMAN (10-470): 8.16e-10: 65.3: 9.07		SIK2_HUMAN (10-340): 1.75e-85: 286: 42.69