HitPredict

Interactor 1: KDM1A (O60341)
Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)
Gene: KDM1A

Interactor 2: HM20A (Q9NP66)
High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1)
Gene: HMG20A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	26496610, 28514442, 27173435, 25639869, 33961781, 16140033, 21258344
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 852 Hs			1 347
+	Mm
		1169785 KDM1A_MOUSE (1-852): 0: 922: 97.30		HM20A_MOUSE (1-347): 4.1e-77: 242: 95.97
+	Hs
		232557 KDM1A_HUMAN (1-852): 0: 936: 100.00		HM20B_HUMAN (60-345): 5.54e-68: 217: 50.00
+	Mm
		1169804 KDM1A_MOUSE (1-852): 0: 922: 97.30		HM20B_MOUSE (31-345): 4.87e-68: 217: 47.62
+	Hs
		232444 KDM1A_HUMAN (1-852): 0: 936: 100.00		CIC_HUMAN (27-227): 1.8e-32: 130: 17.24
+	Hs
		232040 KDM1A_HUMAN (1-852): 0: 936: 100.00		SOX2_HUMAN (68-269): 3.13e-31: 121: 15.42
+	Mm
		1169769 KDM1A_MOUSE (1-852): 0: 922: 97.30		CIC_MOUSE (12-227): 4.89e-29: 120: 17.43
+	Mm
		675607 KDM1A_MOUSE (1-852): 0: 922: 97.30		HMGB2_MOUSE (99-264): 1.59e-09: 59.2: 22.62
+	Zm
		9154 A0A1D6K7D0_MAIZE (103-840): 2.57e-171: 543: 29.25		A0A1D6EUM9_MAIZE (77-206): 3.14e-29: 112: 21.37
+	Hs
		1251597 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		SMCE1_HUMAN (109-299): 6.51e-34: 130: 20.00
+	Hs
		1272916 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		SMCE1_HUMAN (109-299): 6.51e-34: 130: 20.00
+	Hs
		1272921 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		CIC_HUMAN (27-227): 1.8e-32: 130: 17.24
+	Mm
		222670 SMRC1_MOUSE (34-300): 3.24e-58: 218: 17.65		SMCE1_MOUSE (109-299): 1.02e-32: 127: 20.00
+	Hs
		996811 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		SSRP1_HUMAN (1-266): 7.41e-32: 128: 16.30
+	Mm
		956815 SMRC1_MOUSE (34-300): 3.24e-58: 218: 17.65		Q60I23_MOUSE (65-269): 2.85e-31: 122: 15.21
+	Mm
		818694 SMRC1_MOUSE (34-300): 3.24e-58: 218: 17.65		SOX2_MOUSE (65-269): 5.13e-31: 121: 15.21
+	Mm
		1142003 SMRC2_MOUSE (5-300): 1.94e-57: 216: 15.14		Q60I23_MOUSE (65-269): 2.85e-31: 122: 15.21
+	Hs
		818277 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		SOX2_HUMAN (68-269): 3.13e-31: 121: 15.42
+	Hs
		818323 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		SOX2_HUMAN (68-269): 3.13e-31: 121: 15.42
+	Hs
		818822 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		SOX9_HUMAN (10-266): 5.98e-30: 121: 13.21
+	Hs
		818829 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		SOX9_HUMAN (10-266): 5.98e-30: 121: 13.21