Protein: RB6I2
ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)

Gene: RB6I2, ERC1
Organism: Homo sapiens
Interactions: 181
UniProt ID: Q8IUD2

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002102 - podosome
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

177123

ERC2
ERC protein 2

2

18

High-throughput

0.754

High

966573

1433G
14-3-3 protein gamma

6

20

High-throughput

0.732

High

1307176

KBTB7
Kelch repeat and BTB domain-containing protein 7

5

6

Small-scale

0.714

High

730029

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.709

High

631668

RAB6A
Ras-related protein Rab-6A

1

14

Small-scale

0.680

High

691210

1433T
14-3-3 protein theta

4

20

High-throughput

0.678

High

1049523

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

1307207

RAB6B
Ras-related protein Rab-6B

1

16

Small-scale

0.647

High

724693

MK04
Mitogen-activated protein kinase 4

2

14

High-throughput

0.628

High

1152139

MARE1
Microtubule-associated protein RP/EB family member 1

2

2

High-throughput

0.628

High

375690

RASK
GTPase KRas

1

13

High-throughput

0.618

High

1307163

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

18

High-throughput

0.618

High

1115787

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

20

High-throughput

0.614

High

159735

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

18

High-throughput

0.611

High

167929

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

20

Small-scale

0.611

High

1226158

CP135
Centrosomal protein of 135 kDa

2

17

High-throughput

0.611

High

1307219

NEMO
NF-kappa-B essential modulator

2

20

Small-scale

0.611

High

377130

TSHB
Thyrotropin subunit beta

2

0

High-throughput

0.602

High

1143397

PCM1
Pericentriolar material 1 protein

2

1

High-throughput

0.584

High

1307166

NIN
Ninein

2

20

High-throughput

0.584

High

1307203

ANLN
Anillin

2

9

High-throughput

0.584

High

1307193

CDK19
Cyclin-dependent kinase 19

2

19

High-throughput

0.574

High

703958

DUS1
Dual specificity protein phosphatase 1

2

7

High-throughput

0.571

High

1307181

SH3K1
SH3 domain-containing kinase-binding protein 1

2

14

High-throughput

0.571

High

290068

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.559

High

162010

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

20

High-throughput

0.536

High

177905

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.536

High

279185

ULK1
Serine/threonine-protein kinase ULK1

1

12

High-throughput

0.536

High

290332

KS6A4
Ribosomal protein S6 kinase alpha-4

1

11

High-throughput

0.536

High

341614

EYA4
Protein phosphatase EYA4

1

6

High-throughput

0.536

High

391331

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

530045

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.536

High

789164

NUP62
Nuclear pore glycoprotein p62

1

9

High-throughput

0.536

High

867259

CAPZB
F-actin-capping protein subunit beta

1

8

High-throughput

0.536

High

897330

CDK7
Cyclin-dependent kinase 7

1

16

High-throughput

0.536

High

971744

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.536

High

1035753

KIF23
Kinesin-like protein KIF23

1

15

High-throughput

0.536

High

1038575

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

5

High-throughput

0.536

High

1093144

STK4
Serine/threonine-protein kinase 4

1

20

High-throughput

0.536

High

1113613

CUL3
Cullin-3

1

11

High-throughput

0.536

High

1227005

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.536

High

1307167

CE112
Centrosomal protein of 112 kDa

1

20

High-throughput

0.536

High

1307173

MK15
Mitogen-activated protein kinase 15

1

14

High-throughput

0.536

High

246733

KDM1A
Lysine-specific histone demethylase 1A

2

6

High-throughput

0.533

High

728605

AKT2
RAC-beta serine/threonine-protein kinase

1

13

High-throughput

0.515

High

1233705

TWF2
Twinfilin-2

1

11

High-throughput

0.515

High

1273204

CHSTF
Carbohydrate sulfotransferase 15

1

0

High-throughput

0.513

High

422499

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

508242

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.501

High

1006520

SRPK2
SRSF protein kinase 2

1

18

High-throughput

0.501

High

189985

MOT7
Monocarboxylate transporter 7

1

4

High-throughput

0.489

High

281365

GGYF1
GRB10-interacting GYF protein 1

1

10

High-throughput

0.489

High

300668

KRT37
Keratin, type I cuticular Ha7

1

17

High-throughput

0.489

High

300787

KRT38
Keratin, type I cuticular Ha8

1

17

High-throughput

0.489

High

372491

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.489

High

606135

DESM
Desmin

1

18

High-throughput

0.489

High

908213

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

9

High-throughput

0.489

High

1016346

SERF2
Small EDRK-rich factor 2

1

1

High-throughput

0.489

High

1182840

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

7

High-throughput

0.489

High

1307164

CDK20
Cyclin-dependent kinase 20

1

16

High-throughput

0.489

High

1307183

SGK3
Serine/threonine-protein kinase Sgk3

1

12

High-throughput

0.489

High

1307184

ULK4
Serine/threonine-protein kinase ULK4

1

13

High-throughput

0.489

High

1307194

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

12

High-throughput

0.489

High

1307196

RGAP1
Rac GTPase-activating protein 1

1

12

High-throughput

0.489

High

1307214

ING1
Inhibitor of growth protein 1

1

9

High-throughput

0.489

High

1307209

ITSN2
Intersectin-2

1

10

High-throughput

0.481

High

157579

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.479

High

163999

NDC80
Kinetochore protein NDC80 homolog

1

19

High-throughput

0.479

High

213960

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

Small-scale

0.479

High

242192

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

324169

CE152
Centrosomal protein of 152 kDa

1

18

High-throughput

0.479

High

346032

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

10

High-throughput

0.479

High

436925

K1C18
Keratin, type I cytoskeletal 18

1

5

High-throughput

0.479

High

437256

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

459663

PROF1
Profilin-1

1

2

High-throughput

0.479

High

468566

HS90B
Heat shock protein HSP 90-beta

1

14

High-throughput

0.479

High

548349

CP2C9
Cytochrome P450 2C9

1

1

High-throughput

0.479

High

552627

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

4

High-throughput

0.479

High

556194

CADH1
Cadherin-1

1

5

High-throughput

0.479

High

683483

IKBA
NF-kappa-B inhibitor alpha

1

7

Small-scale

0.479

High

766675

PHB1
Prohibitin 1

1

11

High-throughput

0.479

High

785277

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.479

High

799272

BRCA1
Breast cancer type 1 susceptibility protein

1

15

High-throughput

0.479

High

855468

ATRX
Transcriptional regulator ATRX

1

17

Small-scale

0.479

High

862275

YAP1
Transcriptional coactivator YAP1

1

16

High-throughput

0.479

High

891228

GSK3A
Glycogen synthase kinase-3 alpha

1

18

High-throughput

0.479

High

891659

GSK3B
Glycogen synthase kinase-3 beta

1

20

High-throughput

0.479

High

931557

RD23A
UV excision repair protein RAD23 homolog A

1

4

Small-scale

0.479

High

958141

ARP3
Actin-related protein 3

1

20

High-throughput

0.479

High

990456

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1016088

RL19
Large ribosomal subunit protein eL19

1

2

High-throughput

0.479

High

1022741

XIAP
E3 ubiquitin-protein ligase XIAP

1

5

Small-scale

0.479

High

1026454

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1033056

EWS
RNA-binding protein EWS

1

8

High-throughput

0.479

High

1033720

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

1104211

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

8

High-throughput

0.479

High

1109866

HDAC1
Histone deacetylase 1

1

17

High-throughput

0.479

High

1110645

DCTN2
Dynactin subunit 2

1

2

High-throughput

0.479

High

1140513

KIF14
Kinesin-like protein KIF14

1

14

High-throughput

0.479

High

1153829

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.479

High

1197006

AMOT
Angiomotin

1

20

High-throughput

0.479

High

1215470

CE162
Centrosomal protein of 162 kDa

1

19

High-throughput

0.479

High

1248148

SAS6
Spindle assembly abnormal protein 6 homolog

1

19

High-throughput

0.479

High

1252114

SYNE3
Nesprin-3

1

20

High-throughput

0.479

High

1254504

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

1256504

CE128
Centrosomal protein of 128 kDa

1

19

High-throughput

0.479

High

1280872

CNTRL
Centriolin

1

19

High-throughput

0.479

High

1307170

FLCN
Folliculin

1

1

Small-scale

0.479

High

1307172

LNX1
E3 ubiquitin-protein ligase LNX

1

18

Small-scale

0.479

High

1307174

BICD2
Protein bicaudal D homolog 2

1

20

High-throughput

0.479

High

1307175

FBF1
Fas-binding factor 1

1

20

High-throughput

0.479

High

1307177

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

4

High-throughput

0.479

High

1307178

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

11

High-throughput

0.479

High

1307179

GOGA1
Golgin subfamily A member 1

1

19

High-throughput

0.479

High

1307185

BICD1
Protein bicaudal D homolog 1

1

20

High-throughput

0.479

High

1307187

SCLT1
Sodium channel and clathrin linker 1

1

20

High-throughput

0.479

High

1307188

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.479

High

1307189

CEP89
Centrosomal protein of 89 kDa

1

20

High-throughput

0.479

High

1307192

PCGF1
Polycomb group RING finger protein 1

1

12

High-throughput

0.479

High

1307195

WWTR1
WW domain-containing transcription regulator protein 1

1

13

High-throughput

0.479

High

1307198

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1307199

NANOG
Homeobox protein NANOG

1

4

High-throughput

0.479

High

1307200

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

4

High-throughput

0.479

High

1307202

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

6

Small-scale

0.479

High

1307206

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.479

High

1307211

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1307216

MYO6
Unconventional myosin-VI

1

20

High-throughput

0.479

High

1307218

NINL
Ninein-like protein

1

20

High-throughput

0.479

High

245335

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.458

High

1307186

BROMI
Protein broad-minded

1

0

Small-scale

0.458

High

1307197

DNJC5
DnaJ homolog subfamily C member 5

1

4

High-throughput

0.457

High

1307205

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.457

High

58856

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

5

High-throughput

0.445

High

934828

TERA
Transitional endoplasmic reticulum ATPase

1

9

High-throughput

0.445

High

1034020

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

1203183

ODFP2
Outer dense fiber protein 2

1

19

High-throughput

0.445

High

1286583

SDCG8
Serologically defined colon cancer antigen 8

1

19

Small-scale

0.445

High

1288892

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

20

High-throughput

0.445

High

1307165

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.445

High

122519

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

3

High-throughput

0.437

High

278886

PEX14
Peroxisomal membrane protein PEX14

1

2

High-throughput

0.437

High

353433

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.437

High

451407

NFM
Neurofilament medium polypeptide

1

20

High-throughput

0.437

High

475622

K1C19
Keratin, type I cytoskeletal 19

1

4

High-throughput

0.437

High

642959

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.437

High

648578

FGFR4
Fibroblast growth factor receptor 4

1

6

High-throughput

0.437

High

652538

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

16

High-throughput

0.437

High

702008

TMOD1
Tropomodulin-1

1

8

High-throughput

0.437

High

878501

PAXI
Paxillin

1

15

High-throughput

0.437

High

1093656

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

2

High-throughput

0.437

High

1138371

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.437

High

1141754

EEA1
Early endosome antigen 1

1

20

High-throughput

0.437

High

1156538

CCDC6
Coiled-coil domain-containing protein 6

1

20

High-throughput

0.437

High

1197524

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

12

High-throughput

0.437

High

1241900

FBX42
F-box only protein 42

1

11

High-throughput

0.437

High

1248992

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1289434

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.437

High

1291818

T200A
Transmembrane protein 200A

1

1

High-throughput

0.437

High

1307180

VP33A
Vacuolar protein sorting-associated protein 33A

1

4

High-throughput

0.437

High

1307182

PF21A
PHD finger protein 21A

1

17

High-throughput

0.437

High

1307190

SEC62
Translocation protein SEC62

1

2

High-throughput

0.437

High

1307191

MACD1
ADP-ribose glycohydrolase MACROD1

1

6

Small-scale

0.437

High

1307201

MED4
Mediator of RNA polymerase II transcription subunit 4

1

2

High-throughput

0.437

High

1307210

SEP10
Septin-10

1

4

High-throughput

0.437

High

1307213

ANC2
Anaphase-promoting complex subunit 2

1

12

High-throughput

0.437

High

1307215

RCOR1
REST corepressor 1

1

7

High-throughput

0.437

High

1307217

TRI33
E3 ubiquitin-protein ligase TRIM33

1

16

High-throughput

0.437

High

330233

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

1258494

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.407

High

1273844

MICA3
[F-actin]-monooxygenase MICAL3

1

20

Small-scale

0.407

High

1307212

PARP2
Poly [ADP-ribose] polymerase 2

1

4

Small-scale

0.407

High

1307204

TLR9
Toll-like receptor 9

1

0

High-throughput

0.365

High

1307208

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

3

0

High-throughput

0.347

High

1307168

CBY2
Protein chibby homolog 2

2

0

High-throughput

0.328

High

935759

MFAP4
Microfibril-associated glycoprotein 4

1

0

High-throughput

0.279

Low

1179809

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

1251826

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.279

Low

1307171

RASF8
Ras association domain-containing protein 8

1

0

High-throughput

0.269

Low

1307169

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1233886

K0930
Uncharacterized protein KIAA0930

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025