HitPredict

Interactor 1: CCNT1 (O60563)
Cyclin-T1 (CycT1) (Cyclin-T)
Gene: CCNT1

Interactor 2: CLK3 (P49761)
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Gene: CLK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 726 Hs			1 638
+	Hs
		236723 CCNT1_HUMAN (1-715): 0: 591: 100.00		CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52
+	Hs
		236811 CCNT1_HUMAN (1-715): 0: 591: 100.00		DYRK2_HUMAN (93-633): 2.19e-117: 364: 23.45
+	Hs
		236679 CCNT1_HUMAN (1-715): 0: 591: 100.00		CDK1_HUMAN (301-624): 5.68e-119: 357: 24.70
+	Hs
		625350 CCNA1_HUMAN (4-273): 9.89e-86: 280: 16.24		CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26
+	Mm
		956329 CCNA1_MOUSE (4-274): 4.65e-86: 279: 16.54		CDK2_MOUSE (301-631): 2.42e-127: 381: 21.50
+	Hs
		538471 CCNB1_HUMAN (4-281): 4e-75: 250: 12.95		CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26
+	Hs
		414855 CCNA1_HUMAN (4-273): 9.89e-86: 280: 16.24		CDK1_HUMAN (301-624): 5.68e-119: 357: 24.70
+	Hs
		538521 CCNB1_HUMAN (4-281): 4e-75: 250: 12.95		CDK3_HUMAN (301-632): 2.49e-129: 384: 23.89
+	At
		621697 CCA31_ARATH (1-274): 9.12e-80: 260: 13.17		CDKA1_ARATH (301-623): 2.57e-123: 368: 23.33
+	At
		621661 CCB12_ARATH (4-273): 6.27e-77: 256: 13.33		CDKA1_ARATH (301-623): 2.57e-123: 368: 23.33
+	At
		1247203 CCL11_ARATH (6-408): 2.47e-76: 253: 20.95		Q9CAG1_ARATH (13-638): 8.97e-118: 369: 15.22
+	At
		621662 CCA21_ARATH (16-276): 1.32e-75: 252: 12.41		CDKA1_ARATH (301-623): 2.57e-123: 368: 23.33
+	At
		621689 CCA32_ARATH (1-276): 8.09e-75: 248: 13.68		CDKA1_ARATH (301-623): 2.57e-123: 368: 23.33
+	At
		621704 CCB23_ARATH (4-269): 3.37e-74: 248: 15.79		CDKA1_ARATH (301-623): 2.57e-123: 368: 23.33
+	At
		621653 CCA22_ARATH (18-276): 6.38e-74: 247: 13.91		CDKA1_ARATH (301-623): 2.57e-123: 368: 23.33
+	Dm
		830239 Q961D1_DROME (9-334): 1.69e-76: 253: 25.52		MNB_DROME (197-626): 2.53e-113: 362: 27.19
+	Dm
		618404 Q961D1_DROME (9-334): 1.69e-76: 253: 25.52		CDK1_DROME (301-622): 2.22e-118: 356: 26.06
+	Hs
		414711 CCNB1_HUMAN (4-281): 4e-75: 250: 12.95		CDK1_HUMAN (301-624): 5.68e-119: 357: 24.70
+	Dm
		540472 CCNA_DROME (4-304): 9.42e-74: 249: 14.90		CDK1_DROME (301-622): 2.22e-118: 356: 26.06
+	Mm
		509465 CCNB1_MOUSE (4-268): 4.73e-75: 250: 14.61		CDK1_MOUSE (301-624): 1.05e-117: 354: 24.10