HitPredict

Interactor 1: TLR5 (O60602)
Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
Gene: TLR5

Interactor 2: CNPY3 (Q9BT09)
Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein)
Gene: CNPY3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045087 - innate immune response
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 858 Hs			1 278
+	Hs
		1311701 TLR8_HUMAN (2-846): 2.26e-100: 337: 20.25		CNPY3_HUMAN (1-278): 9.66e-149: 419: 100.00
+	Hs
		728889 ALS_HUMAN (24-626): 1.34e-76: 262: 24.73		CNPY3_HUMAN (1-278): 9.66e-149: 419: 100.00
+	Hs
		120174 TLR4_HUMAN (2-229): 1.83e-22: 105: 17.19		CNPY3_HUMAN (1-278): 9.66e-149: 419: 100.00
+	Hs
		1311700 TLR9_HUMAN (233-587): 6.35e-21: 100: 18.29		CNPY3_HUMAN (1-278): 9.66e-149: 419: 100.00
+	Hs
		770238 GPV_HUMAN (290-624): 8.04e-19: 93.2: 28.81		CNPY3_HUMAN (1-278): 9.66e-149: 419: 100.00
+	Hs
		200348 LRRT2_HUMAN (270-536): 1.39e-18: 92: 30.82		CNPY3_HUMAN (1-278): 9.66e-149: 419: 100.00
+	Hs
		1311684 TLR10_HUMAN (262-662): 1.04e-14: 80.6: 13.22		CNPY3_HUMAN (1-278): 9.66e-149: 419: 100.00
+	Hs
		1073331 TLR1_HUMAN (249-574): 3.69e-12: 72.2: 13.67		CNPY3_HUMAN (1-278): 9.66e-149: 419: 100.00
+	Hs
		770229 GPV_HUMAN (290-624): 8.04e-19: 93.2: 28.81		CNPY4_HUMAN (17-215): 2.14e-110: 320: 48.00
+	Hs
		200345 LRRT2_HUMAN (270-536): 1.39e-18: 92: 30.82		CNPY4_HUMAN (17-215): 2.14e-110: 320: 48.00
+	Mm
		1207142 TLR4_MOUSE (182-684): 2.6e-12: 72.9: 16.14		CNPY4_MOUSE (10-215): 4.22e-111: 322: 47.34