HitPredict

Interactor 1: DIAP1 (O60610)
Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1)
Gene: DIAPH1

Interactor 2: PROF2 (P35080)
Profilin-2 (Profilin II)
Gene: PFN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm GO:0030036 - actin cytoskeleton organization
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1272 Hs			1 140
+	Hs
		237549 DIAP1_HUMAN (1-1272): 0: 953: 100.00		PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43
+	Hs
		243087 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43
+	Hs
		430352 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43
+	Hs
		715022 FHOD1_HUMAN (25-581): 8.51e-72: 264: 13.38		PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00
+	Hs
		430404 FHOD1_HUMAN (25-581): 8.51e-72: 264: 13.38		PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43
+	Hs
		430307 FMNL2_HUMAN (68-653): 1.92e-65: 244: 14.36		PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43
+	Hs
		714970 INF2_HUMAN (117-606): 5.39e-59: 224: 21.70		PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00
+	Hs
		430197 INF2_HUMAN (117-606): 5.39e-59: 224: 21.70		PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43
+	Hs
		314847 FMNL1_HUMAN (86-641): 3.73e-57: 218: 18.14		PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00
+	Hs
		314830 FMNL1_HUMAN (86-641): 3.73e-57: 218: 18.14		PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43