HitPredict

Interactor 1: PLPL9 (O60733)
85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (2-lysophosphatidylcholine acylhydrolase) (EC 3.1.1.5) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9)
Gene: PLA2G6

Interactor 2: PLPL9 (O60733)
85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (2-lysophosphatidylcholine acylhydrolase) (EC 3.1.1.5) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9)
Gene: PLA2G6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.843

The method score is based on:

Property Details
Experiments 32296183, 15385540, unassigned1304
Identification Methods two hybrid, affinity chromatography technology, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank~Ank, Ank~Ank_2, Ank_2~Ank_2, Ank_2~Patatin, Patatin~Patatin
Common GO terms GO:0003847 - 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0004622 - lysophospholipase activity
GO:0004623 - phospholipase A2 activity
GO:0005516 - calmodulin binding
GO:0005615 - extracellular space
and 22 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 806
Hs

1 806
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Dr
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024