HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030425 - dendrite
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 918
+	Hs
		239737 HCN1_HUMAN (1-890): 0: 684: 100.00		PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38
+	Hs
		239975 HCN1_HUMAN (1-890): 0: 684: 100.00		PTPRS_HUMAN (22-914): 1.28e-78: 282: 11.66
+	Hs
		239784 HCN1_HUMAN (1-890): 0: 684: 100.00		PTPRD_HUMAN (1-897): 2.19e-59: 223: 11.86
+	Hs
		239967 HCN1_HUMAN (1-890): 0: 684: 100.00		CNTN1_HUMAN (27-915): 3.52e-47: 184: 9.82
+	Hs
		240124 HCN1_HUMAN (1-890): 0: 684: 100.00		NEO1_HUMAN (128-882): 5.57e-27: 120: 10.99
+	Hs
		239838 HCN1_HUMAN (1-890): 0: 684: 100.00		LIFR_HUMAN (127-619): 3.5e-24: 111: 13.30
+	Hs
		239813 HCN1_HUMAN (1-890): 0: 684: 100.00		L1CAM_HUMAN (121-918): 4.49e-22: 105: 10.00
+	Hs
		240072 HCN1_HUMAN (1-890): 0: 684: 100.00		SDK1_HUMAN (249-918): 1.67e-14: 80.5: 9.65
+	Hs
		240114 HCN1_HUMAN (1-890): 0: 684: 100.00		TITIN_HUMAN (16-496): 1.42e-10: 67.7: 8.82
+	Mm
		57583 KCNH2_MOUSE (3-883): 1.77e-167: 519: 18.01		TITIN_MOUSE (26-461): 9.95e-10: 65: 12.66