HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	EF-hand_7~Ion_trans
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 2472
+	Hs
		164538 HCN1_HUMAN (1-890): 0: 684: 100.00		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		239659 HCN1_HUMAN (1-890): 0: 684: 100.00		K0754_HUMAN (1-1482): 9.32e-58: 225: 14.65
+	Mm
		292129 HCN1_MOUSE (1-890): 0: 651: 90.35		Q68FG2_MOUSE (141-1932): 3.76e-63: 242: 20.06
+	Hs
		239945 HCN1_HUMAN (1-890): 0: 684: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		239952 HCN1_HUMAN (1-890): 0: 684: 100.00		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		240002 HCN1_HUMAN (1-890): 0: 684: 100.00		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Mm
		292126 HCN1_MOUSE (1-890): 0: 651: 90.35		SPTB2_MOUSE (1408-2420): 1.22e-29: 132: 18.86
+	Hs
		211437 HCN1_HUMAN (1-890): 0: 684: 100.00		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15