HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: EMAL2 (O95834)
Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2)
Gene: EML2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0015631 - tubulin binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 649
+	Hs
		242988 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		EMAL4_HUMAN (3-649): 9.66e-145: 447: 54.85
+	Hs
		242627 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		CFA57_HUMAN (59-648): 1.5e-140: 442: 19.85
+	Hs
		335184 ARI2_HUMAN (222-464): 9.66e-64: 215: 20.82		EMAL4_HUMAN (3-649): 9.66e-145: 447: 54.85
+	Hs
		242841 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		TBL1R_HUMAN (3-282): 4.39e-51: 186: 12.89
+	Hs
		241521 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		TBL3_HUMAN (301-648): 3.32e-47: 180: 12.57
+	Hs
		243097 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		NLE1_HUMAN (4-278): 1.08e-48: 179: 10.03
+	Hs
		241769 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		TAF5_HUMAN (101-378): 1e-16: 86.3: 18.75
+	Hs
		161686 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		APAF_HUMAN (545-647): 2.01e-12: 72.9: 16.51
+	Hs
		246260 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		MABP1_HUMAN (18-614): 2.05e-61: 224: 10.76
+	Hs
		507321 UBB_HUMAN (1-234): 4.43e-61: 200: 17.92		WDR90_HUMAN (46-447): 5.11e-32: 135: 15.08
+	Sc
		509510 UBI4P_YEAST (1-229): 3.44e-60: 203: 18.72		TAF5_YEAST (145-480): 4.85e-18: 90.5: 18.23