HitPredict

Interactor 1: H2B1K (O60814)
Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1)
Gene: H2BC12

Interactor 2: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25963833, 34349018
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 904
+	Hs
		832512 H2B2F_HUMAN (1-126): 2.19e-54: 168: 97.62		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		617935 H2B1O_HUMAN (1-126): 2.88e-54: 167: 97.62		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832673 H2B1M_HUMAN (1-126): 4.46e-54: 167: 96.03		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		420814 H2B1J_HUMAN (1-126): 6.13e-54: 166: 99.21		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832322 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832624 H2B1H_HUMAN (1-126): 5.43e-54: 166: 98.41		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		241460 H2B1K_HUMAN (1-126): 1.2e-53: 166: 100.00		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		708414 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		708456 H2B2E_HUMAN (1-126): 5.55e-54: 166: 98.41		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		708674 H2B2F_HUMAN (1-126): 2.19e-54: 168: 97.62		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		617930 H2B1O_HUMAN (1-126): 2.88e-54: 167: 97.62		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708749 H2B1M_HUMAN (1-126): 4.46e-54: 167: 96.03		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		241461 H2B1K_HUMAN (1-126): 1.2e-53: 166: 100.00		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		420809 H2B1J_HUMAN (1-126): 6.13e-54: 166: 99.21		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708596 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708664 H2B2E_HUMAN (1-126): 5.55e-54: 166: 98.41		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708719 H2B1H_HUMAN (1-126): 5.43e-54: 166: 98.41		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		627278 H2B2E_HUMAN (1-126): 5.55e-54: 166: 98.41		MCM3_HUMAN (186-897): 0: 725: 29.20
+	Hs
		1055603 H2B1H_HUMAN (1-126): 5.43e-54: 166: 98.41		MCM6_HUMAN (186-817): 0: 710: 31.18
+	Hs
		241525 H2B1K_HUMAN (1-126): 1.2e-53: 166: 100.00		MCM6_HUMAN (186-817): 0: 710: 31.18