Protein: ASNS
Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) (Cell cycle control protein TS11) (Glutamine-dependent asparagine synthetase)

Gene: ASNS
Organism: Homo sapiens
Interactions: 124
UniProt ID: P08243

Gene Ontology (top 5):
GO:0004066 - asparagine synthase (glutamine-hydrolyzing) activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006529 - asparagine biosynthetic process
GO:0042149 - cellular response to glucose starvation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

469303

TRI69
E3 ubiquitin-protein ligase TRIM69

4

2

High-throughput

0.698

High

469246

HSP7C
Heat shock cognate 71 kDa protein

4

2

High-throughput

0.678

High

240533

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

469278

RL7A
Large ribosomal subunit protein eL8

2

0

High-throughput

0.576

High

469318

OTUB1
Ubiquitin thioesterase OTUB1

2

1

High-throughput

0.571

High

469347

SHOC2
Leucine-rich repeat protein SHOC-2

2

1

High-throughput

0.571

High

469293

TRIP4
Activating signal cointegrator 1

2

0

High-throughput

0.559

High

469273

ATX1
Ataxin-1

1

3

High-throughput

0.541

High

469310

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.536

High

469312

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

2

High-throughput

0.536

High

469314

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.536

High

469350

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

259326

BRD4
Bromodomain-containing protein 4

2

5

High-throughput

0.533

High

469250

CEBPB
CCAAT/enhancer-binding protein beta

2

2

Small-scale

0.533

High

60208

WDR27
WD repeat-containing protein 27

1

3

High-throughput

0.523

High

469253

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.521

High

407026

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

469248

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.513

High

469319

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

469328

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

469332

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

469337

PICK1
PRKCA-binding protein

1

0

High-throughput

0.513

High

469338

STRN4
Striatin-4

1

3

High-throughput

0.494

High

469349

RNF11
RING finger protein 11

1

2

High-throughput

0.489

High

258729

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.479

High

293087

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

315032

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

345275

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

362627

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

370967

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

411214

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

463883

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

8

High-throughput

0.479

High

469245

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

469254

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

469256

FGFR4
Fibroblast growth factor receptor 4

1

8

High-throughput

0.479

High

469257

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

469258

TTP
mRNA decay activator protein ZFP36

1

1

High-throughput

0.479

High

469262

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

469263

HS71L
Heat shock 70 kDa protein 1-like

1

2

High-throughput

0.479

High

469266

VGFR3
Vascular endothelial growth factor receptor 3

1

4

High-throughput

0.479

High

469267

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

469268

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

469271

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

469275

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

469277

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

469281

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

469282

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

469285

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

469287

CUL3
Cullin-3

1

5

High-throughput

0.479

High

469295

NTRK3
NT-3 growth factor receptor

1

6

High-throughput

0.479

High

469299

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

469300

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.479

High

469308

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

469313

HDAC2
Histone deacetylase 2

1

3

High-throughput

0.479

High

469317

OTUL
Ubiquitin thioesterase otulin

1

1

Small-scale

0.479

High

469321

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

3

Small-scale

0.479

High

469323

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

469324

NECD
Necdin

1

1

High-throughput

0.479

High

469325

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.479

High

469326

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

469330

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.479

High

469339

DUS22
Dual specificity protein phosphatase 22

1

1

High-throughput

0.479

High

469342

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

469343

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

469345

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

1

High-throughput

0.479

High

469346

ALK
ALK tyrosine kinase receptor

1

5

High-throughput

0.479

High

125159

LEG9
Galectin-9

1

0

High-throughput

0.458

High

319314

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

469252

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.458

High

469255

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

469260

T2EA
General transcription factor IIE subunit 1

1

0

Small-scale

0.458

High

469265

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

469272

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.458

High

469274

EPHA5
Ephrin type-A receptor 5

1

0

High-throughput

0.458

High

469279

RHOB
Rho-related GTP-binding protein RhoB

1

0

High-throughput

0.458

High

469286

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

469290

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

469294

STXB2
Syntaxin-binding protein 2

1

0

High-throughput

0.458

High

469311

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

469315

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

469320

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

469341

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

469344

TES
Testin

1

0

High-throughput

0.458

High

469276

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.457

High

469298

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

469348

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

469247

ITA4
Integrin alpha-4

1

1

High-throughput

0.437

High

469249

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

469251

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

3

Small-scale

0.437

High

469259

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

469264

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

469280

TF2B
Transcription initiation factor IIB

1

4

Small-scale

0.437

High

469283

MMRN1
Multimerin-1

1

1

High-throughput

0.437

High

469284

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.437

High

469288

TRI14
Tripartite motif-containing protein 14

1

3

High-throughput

0.437

High

469296

DUS28
Dual specificity phosphatase 28

1

1

High-throughput

0.437

High

469301

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

469302

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

469304

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

4

Small-scale

0.437

High

469307

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.437

High

469334

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

469335

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

469336

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.437

High

469289

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.426

High

469292

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

429167

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

469309

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

469333

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.407

High

469270

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.373

High

469327

SH3G3
Endophilin-A3

2

0

High-throughput

0.298

High

252742

AP180
Clathrin coat assembly protein AP180

1

0

High-throughput

0.279

Low

469261

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

469329

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

469306

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.269

Low

324431

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

469269

PERI
Peripherin

1

0

High-throughput

0.249

Low

469291

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

469297

FA78A
Protein FAM78A

1

0

High-throughput

0.249

Low

469305

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.249

Low

469316

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

469322

DNJC1
DnaJ homolog subfamily C member 1

1

0

High-throughput

0.249

Low

469340

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.249

Low

3669

NBDY
Negative regulator of P-body association

1

0

Small-scale

0.232

Low

469331

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025