Protein: GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (GFAT) (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (Hexosephosphate aminotransferase)

Gene: GFA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 222
UniProt ID: P14742

Gene Ontology (top 5):
GO:0004360 - glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0006002 - fructose 6-phosphate metabolic process
GO:0006031 - chitin biosynthetic process
GO:0006047 - UDP-N-acetylglucosamine metabolic process
GO:0006048 - UDP-N-acetylglucosamine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

575471

EMW1
Essential for maintenance of the cell wall protein 1

3

2

High-throughput

0.579

High

575510

GCN5
Histone acetyltransferase GCN5

2

5

High-throughput

0.574

High

575396

RAD51
DNA repair protein RAD51

2

2

High-throughput

0.567

High

575407

IMB3
Importin subunit beta-3

2

2

High-throughput

0.567

High

575448

RPN10
26S proteasome regulatory subunit RPN10

2

3

High-throughput

0.567

High

575544

RUVB2
RuvB-like protein 2

2

2

High-throughput

0.558

High

509370

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

4

High-throughput

0.543

High

575474

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.533

High

392139

HSP82
ATP-dependent molecular chaperone HSP82

2

6

High-throughput

0.521

High

543674

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.521

High

575515

RUVB1
RuvB-like protein 1

2

2

High-throughput

0.521

High

575462

SSB2
Ribosome-associated molecular chaperone SSB2

2

8

High-throughput

0.504

High

368314

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

1

High-throughput

0.489

High

399335

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

3

High-throughput

0.489

High

470446

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

4

High-throughput

0.489

High

486397

TBA3
Tubulin alpha-3 chain

1

4

High-throughput

0.489

High

574622

KSS1
Mitogen-activated protein kinase KSS1

1

1

High-throughput

0.489

High

575381

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

4

High-throughput

0.489

High

575382

DBF2
Cell cycle protein kinase DBF2

1

2

High-throughput

0.489

High

575404

PRR1
Serine/threonine-protein kinase PRR1

1

1

High-throughput

0.489

High

575423

GCN1
eIF-2-alpha kinase activator GCN1

1

2

High-throughput

0.489

High

575424

SPT7
SAGA complex subunit SPT7

1

3

High-throughput

0.489

High

575429

KDX1
Serine/threonine-protein kinase KDX1

1

2

High-throughput

0.489

High

575436

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

2

High-throughput

0.489

High

575437

CHK1
Serine/threonine-protein kinase CHK1

1

3

High-throughput

0.489

High

575443

KPR3
Ribose-phosphate pyrophosphokinase 3

1

1

High-throughput

0.489

High

575445

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.489

High

575464

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

575480

MSN5
Protein MSN5

1

1

High-throughput

0.489

High

575484

INO80
Chromatin-remodeling ATPase INO80

1

2

High-throughput

0.489

High

575488

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.489

High

575498

ARP4
Actin-related protein 4

1

1

High-throughput

0.489

High

575501

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.489

High

575543

AHA1
Hsp90 co-chaperone AHA1

1

2

High-throughput

0.489

High

575546

GLT1
Glutamate synthase [NADH]

1

2

High-throughput

0.489

High

575477

CLA4
Serine/threonine-protein kinase CLA4

1

3

High-throughput

0.457

High

575293

EI2BA
Translation initiation factor eIF2B subunit alpha

1

1

High-throughput

0.457

High

575377

GBB
Guanine nucleotide-binding protein subunit beta

1

4

High-throughput

0.457

High

575378

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

3

High-throughput

0.457

High

575388

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

1

High-throughput

0.457

High

575395

DMC1
Meiotic recombination protein DMC1

1

2

High-throughput

0.457

High

575414

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.457

High

575439

IMB2
Importin subunit beta-2

1

2

High-throughput

0.457

High

575453

DUN1
DNA damage response protein kinase DUN1

1

1

High-throughput

0.457

High

575469

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.457

High

575500

AP1M1
AP-1 complex subunit mu-1-I

1

1

High-throughput

0.457

High

575513

WDR59
Maintenance of telomere capping protein 5

1

5

High-throughput

0.457

High

575519

SPC24
Kinetochore protein SPC24

1

1

High-throughput

0.457

High

575548

AP2M
AP-2 complex subunit mu

1

1

High-throughput

0.457

High

464536

PBS2
MAP kinase kinase PBS2

1

2

High-throughput

0.437

High

486006

TBA1
Tubulin alpha-1 chain

1

4

High-throughput

0.437

High

509866

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

2

High-throughput

0.437

High

575385

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

4

High-throughput

0.437

High

575390

SIS1
Protein SIS1

1

6

High-throughput

0.437

High

575398

CDC48
Cell division control protein 48

1

3

High-throughput

0.437

High

575399

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.437

High

575405

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

575416

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.437

High

575419

SMY2
Protein SMY2

1

3

High-throughput

0.437

High

575420

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.437

High

575431

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.437

High

575434

LONM
Lon protease homolog, mitochondrial

1

6

High-throughput

0.437

High

575438

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.437

High

575447

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.437

High

575456

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

575465

FIS1
Mitochondrial fission 1 protein

1

1

Small-scale

0.437

High

575466

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.437

High

575493

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.437

High

575497

H3
Histone H3

1

1

High-throughput

0.437

High

575522

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

575541

DBP10
ATP-dependent RNA helicase DBP10

1

5

High-throughput

0.437

High

394019

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.407

High

440889

CDC7
Cell division control protein 7

1

3

Small-scale

0.407

High

510146

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.407

High

522922

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.407

High

525811

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.407

High

575372

HSC82
ATP-dependent molecular chaperone HSC82

1

6

High-throughput

0.407

High

575383

NPR1
Nitrogen permease reactivator protein

1

2

High-throughput

0.407

High

575401

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.407

High

575406

MCM5
Minichromosome maintenance protein 5

1

4

High-throughput

0.407

High

575410

APE2
Aminopeptidase 2, mitochondrial

1

3

High-throughput

0.407

High

575425

MDJ1
DnaJ homolog 1, mitochondrial

1

5

High-throughput

0.407

High

575446

DBP8
ATP-dependent RNA helicase DBP8

1

2

High-throughput

0.407

High

575460

PIC2
Mitochondrial phosphate carrier protein 2

1

1

High-throughput

0.407

High

575475

NMD5
Nonsense-mediated mRNA decay protein 5

1

1

High-throughput

0.407

High

575489

HCH1
Hsp90 co-chaperone HCH1

1

2

High-throughput

0.407

High

575490

RM22
Large ribosomal subunit protein uL22m

1

1

High-throughput

0.407

High

575491

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.407

High

575518

UTP15
U3 small nucleolar RNA-associated protein 15

1

4

High-throughput

0.407

High

575526

SSK1
Osmolarity two-component system protein SSK1

1

1

High-throughput

0.407

High

575533

HRK1
Serine/threonine-protein kinase HRK1

1

1

High-throughput

0.407

High

575538

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.407

High

575542

ARP7
Actin-related protein 7

1

1

High-throughput

0.407

High

575545

NOP58
Nucleolar protein 58

1

1

High-throughput

0.407

High

575549

DUF1
DUB-associated factor 1

1

4

High-throughput

0.407

High

471365

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

2

0

High-throughput

0.328

High

535971

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

2

0

High-throughput

0.324

High

366634

ARGI
Arginase

2

0

High-throughput

0.313

High

575430

EF1G2
Elongation factor 1-gamma 2

2

0

High-throughput

0.307

High

575435

GLYC
Serine hydroxymethyltransferase, cytosolic

2

0

High-throughput

0.307

High

575442

RMD9L
RNA-binding protein RMD9-like, mitochondrial

2

0

High-throughput

0.307

High

575468

LCB2
Serine palmitoyltransferase 2

2

0

High-throughput

0.307

High

513324

RL23B
Large ribosomal subunit protein uL14B

2

0

High-throughput

0.305

High

558546

CAF20
Cap-associated protein CAF20

2

0

High-throughput

0.305

High

575394

RS2
Small ribosomal subunit protein uS5

2

0

Small-scale

0.305

High

458998

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.279

Low

531227

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.279

Low

550565

SST2
Protein SST2

1

0

High-throughput

0.279

Low

575397

SGF29
SAGA complex subunit SGF29

1

0

High-throughput

0.279

Low

575409

ARP2
Actin-related protein 2

1

0

High-throughput

0.279

Low

575432

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.279

Low

575441

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

575450

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.279

Low

575457

FHP
Flavohemoprotein

1

0

High-throughput

0.279

Low

575470

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.279

Low

575479

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.279

Low

575485

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.279

Low

575486

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.279

Low

575495

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.279

Low

575521

ISR1
Serine/threonine-protein kinase ISR1

1

0

High-throughput

0.279

Low

575529

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.279

Low

575540

IES3
Ino eighty subunit 3

1

0

High-throughput

0.279

Low

575547

SUS1
SAGA complex subunit SUS1

1

0

High-throughput

0.279

Low

575376

CLC1
Clathrin light chain

1

0

High-throughput

0.269

Low

575387

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.269

Low

575417

PDC2
Protein PDC2

1

0

High-throughput

0.269

Low

575511

CEF1
Pre-mRNA-splicing factor CEF1

1

0

High-throughput

0.269

Low

575524

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.269

Low

517869

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.261

Low

575380

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.261

Low

575392

CDC10
Cell division control protein 10

1

0

High-throughput

0.261

Low

575393

RV161
Reduced viability upon starvation protein 161

1

0

High-throughput

0.261

Low

575528

SHS1
Seventh homolog of septin 1

1

0

High-throughput

0.261

Low

383483

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

401855

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.249

Low

409903

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

430763

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

Small-scale

0.249

Low

434777

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

435736

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

454835

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

502810

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504007

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

512223

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

513944

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.249

Low

514419

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

575400

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

575412

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.249

Low

575418

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

575422

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

575426

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

575427

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

575428

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

575433

EAP1
Protein EAP1

1

0

High-throughput

0.249

Low

575440

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.249

Low

575444

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

575458

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.249

Low

575467

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

575472

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

575473

SET4
SET domain-containing protein 4

1

0

Small-scale

0.249

Low

575476

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

575478

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

575499

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

575502

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

575505

ESP1
Separin

1

0

High-throughput

0.249

Low

575514

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

575516

HMO1
High mobility group protein 1

1

0

High-throughput

0.249

Low

575517

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

575530

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

575531

MCA1
Metacaspase-1

1

0

High-throughput

0.249

Low

575534

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

575415

TFB1
General transcription and DNA repair factor IIH subunit TFB1

1

0

High-throughput

0.238

Low

150143

THP2
THO complex subunit THP2

1

0

High-throughput

0.232

Low

150251

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.232

Low

364298

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.232

Low

454068

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.232

Low

456321

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.232

Low

566478

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.232

Low

575373

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.232

Low

575374

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.232

Low

575375

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.232

Low

575379

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.232

Low

575384

SEC15
Exocyst complex component SEC15

1

0

High-throughput

0.232

Low

575386

UBA1
Ubiquitin-activating enzyme E1 1

1

0

High-throughput

0.232

Low

575389

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.232

Low

575391

MSH3
DNA mismatch repair protein MSH3

1

0

High-throughput

0.232

Low

575402

NAM9
Small ribosomal subunit protein uS4m

1

0

High-throughput

0.232

Low

575403

LAC1
Ceramide synthase LAC1

1

0

High-throughput

0.232

Low

575408

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.232

Low

575411

GSH1
Glutamate--cysteine ligase

1

0

High-throughput

0.232

Low

575413

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.232

Low

575421

MFT1
THO complex subunit MFT1

1

0

High-throughput

0.232

Low

575449

SKN7
Transcription factor SKN7

1

0

High-throughput

0.232

Low

575451

ASPG1
L-asparaginase 1

1

0

High-throughput

0.232

Low

575452

HXT7
High-affinity hexose transporter HXT7

1

0

High-throughput

0.232

Low

575454

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

High-throughput

0.232

Low

575455

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.232

Low

575459

FMP52
Protein FMP52, mitochondrial

1

0

High-throughput

0.232

Low

575461

MGDP1
Putative magnesium-dependent phosphatase YER134C

1

0

High-throughput

0.232

Low

575463

VID27
Vacuolar import and degradation protein 27

1

0

High-throughput

0.232

Low

575481

NIF3
NGG1-interacting factor 3

1

0

High-throughput

0.232

Low

575482

MDS3
Negative regulator of sporulation MDS3

1

0

High-throughput

0.232

Low

575483

ARI1
NADPH-dependent aldehyde reductase ARI1

1

0

High-throughput

0.232

Low

575487

MPA43
Protein MPA43

1

0

High-throughput

0.232

Low

575492

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.232

Low

575494

SIW14
Inositol diphosphatase SIW14

1

0

High-throughput

0.232

Low

575496

DOS2
Protein DOS2

1

0

High-throughput

0.232

Low

575503

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.232

Low

575504

UTP6
U3 small nucleolar RNA-associated protein 6

1

0

High-throughput

0.232

Low

575506

FDC1
Ferulic acid decarboxylase 1

1

0

High-throughput

0.232

Low

575507

SVL3
Styryl dye vacuolar localization protein 3

1

0

High-throughput

0.232

Low

575508

PIR1
Cell wall mannoprotein PIR1

1

0

High-throughput

0.232

Low

575509

FCP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.232

Low

575512

ARX1
Probable metalloprotease ARX1

1

0

High-throughput

0.232

Low

575520

YL287
Uncharacterized protein YLR287C

1

0

High-throughput

0.232

Low

575523

FKBP4
FK506-binding protein 4

1

0

High-throughput

0.232

Low

575525

UBX5
UBX domain-containing protein 5

1

0

High-throughput

0.232

Low

575527

NOP6
Nucleolar protein 6

1

0

High-throughput

0.232

Low

575532

FOLE
Folylpolyglutamate synthase

1

0

High-throughput

0.232

Low

575535

TFB6
General transcription and DNA repair factor IIH subunit TFB6

1

0

High-throughput

0.232

Low

575536

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.232

Low

575537

NMD4
Nonsense-mediated decay protein 4

1

0

High-throughput

0.232

Low

575539

UTP23
rRNA-processing protein UTP23

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025