HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: EI2BE (Q13144)
Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon)
Gene: EIF2B5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.56 0.60 0.584

The method score is based on:

Property Details
Experiments 35509820, 35256949
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0034976 - response to endoplasmic reticulum stress
GO:0043065 - positive regulation of apoptotic process
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 465
Hs

1 721
+ Hs
+ Hs
+ Zm
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ At
+ At
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025