Protein: EI2BG
Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma)

Gene: EI2BG, EIF2B3
Organism: Homo sapiens
Interactions: 116
UniProt ID: Q9NR50

Gene Ontology (top 5):
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1124236

EI2BA
Translation initiation factor eIF2B subunit alpha

4

15

High-throughput

0.900

High

890167

EI2BB
Translation initiation factor eIF2B subunit beta

3

15

High-throughput

0.861

High

363905

EGFR
Epidermal growth factor receptor

4

1

Small-scale

0.672

High

1431368

OPN3
Opsin-3

3

5

High-throughput

0.667

High

1447974

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

1

High-throughput

0.667

High

639171

SYT1
Synaptotagmin-1

3

3

High-throughput

0.662

High

1447978

FZD10
Frizzled-10

3

1

High-throughput

0.662

High

1092663

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

3

0

High-throughput

0.638

High

1294842

STX12
Syntaxin-12

4

1

High-throughput

0.630

High

1334416

UXS1
UDP-glucuronic acid decarboxylase 1

2

1

High-throughput

0.628

High

1095949

EI2BE
Translation initiation factor eIF2B subunit epsilon

2

17

Small-scale

0.619

High

1447976

EI2BD
Translation initiation factor eIF2B subunit delta

1

12

High-throughput

0.618

High

592745

LEUK
Leukosialin

3

1

High-throughput

0.609

High

733516

GP183
G-protein coupled receptor 183

3

8

High-throughput

0.609

High

845484

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

7

High-throughput

0.609

High

1399297

NECT4
Nectin-4

3

2

High-throughput

0.609

High

1405350

P2RX4
P2X purinoceptor 4

3

1

High-throughput

0.609

High

1447979

CAH14
Carbonic anhydrase 14

3

1

High-throughput

0.609

High

1330746

SIGL1
SIGLEC family-like protein 1

3

1

High-throughput

0.604

High

1435996

PACC1
Proton-activated chloride channel

3

1

High-throughput

0.604

High

1022970

EFNB1
Ephrin-B1

2

3

High-throughput

0.601

High

243034

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

438105

GLPB
Glycophorin-B

2

2

High-throughput

0.574

High

640300

EPHA1
Ephrin type-A receptor 1

2

1

High-throughput

0.574

High

749281

CD70
CD70 antigen

2

1

High-throughput

0.574

High

1153443

CD226
CD226 antigen

2

3

High-throughput

0.549

High

1291689

CMTD1
Catechol O-methyltransferase domain-containing protein 1

2

1

High-throughput

0.549

High

1331863

SYT2
Synaptotagmin-2

2

3

High-throughput

0.549

High

1447977

CC018
Uncharacterized protein C3orf18

2

1

High-throughput

0.549

High

220202

TNF14
Tumor necrosis factor ligand superfamily member 14

1

1

High-throughput

0.536

High

407133

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.536

High

486623

TACD2
Tumor-associated calcium signal transducer 2

1

1

High-throughput

0.536

High

832131

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

8

High-throughput

0.536

High

933357

IF5
Eukaryotic translation initiation factor 5

1

5

High-throughput

0.536

High

1249853

BTNL9
Butyrophilin-like protein 9

1

1

High-throughput

0.536

High

1370601

FGF14
Fibroblast growth factor 14

1

1

High-throughput

0.536

High

1447980

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

1

High-throughput

0.536

High

302267

STC2
Stanniocalcin-2

1

0

High-throughput

0.518

High

831490

CCNF
Cyclin-F

1

4

High-throughput

0.515

High

329985

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.513

High

721742

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

955643

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.513

High

1420164

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

253907

TPST2
Protein-tyrosine sulfotransferase 2

1

1

High-throughput

0.489

High

669290

PTAFR
Platelet-activating factor receptor

1

8

High-throughput

0.489

High

702853

5HT2C
5-hydroxytryptamine receptor 2C

1

3

High-throughput

0.489

High

762418

BTC
Probetacellulin [Cleaved into: Betacellulin

1

2

High-throughput

0.489

High

1101672

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

10

High-throughput

0.489

High

1142187

P2RY6
P2Y purinoceptor 6

1

8

High-throughput

0.489

High

1286716

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

3

High-throughput

0.489

High

1326573

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

3

High-throughput

0.489

High

1363148

CLC2B
C-type lectin domain family 2 member B

1

2

High-throughput

0.489

High

1404231

SEC62
Translocation protein SEC62

1

1

High-throughput

0.489

High

1430967

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.489

High

1447973

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

1

High-throughput

0.489

High

1447981

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

1

High-throughput

0.489

High

173418

XPO1
Exportin-1

1

7

High-throughput

0.479

High

262317

SCN2B
Sodium channel regulatory subunit beta-2

1

2

High-throughput

0.479

High

1114398

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1255694

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1334965

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1380661

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1383102

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1393728

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

1428375

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.479

High

1433985

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1435336

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1447970

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1447971

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1447975

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

485445

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

607138

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

845995

DCC
Netrin receptor DCC

1

0

Small-scale

0.458

High

902952

DUS3
Dual specificity protein phosphatase 3

1

0

High-throughput

0.458

High

1229702

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1347998

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.458

High

1364612

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1447969

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

1447972

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

0

High-throughput

0.458

High

171585

S27A2
Long-chain fatty acid transport protein 2

1

3

High-throughput

0.445

High

388306

GLPA
Glycophorin-A

1

2

High-throughput

0.445

High

532177

CD28
T-cell-specific surface glycoprotein CD28

1

1

High-throughput

0.445

High

722887

SSR2
Somatostatin receptor type 2

1

6

High-throughput

0.445

High

1209697

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

1227524

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.445

High

1402911

CK5P2
CDK5 regulatory subunit-associated protein 2

1

2

High-throughput

0.445

High

373243

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

589790

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

696604

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

769273

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1103800

PLD1
Phospholipase D1

1

1

High-throughput

0.437

High

1249240

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1276833

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1313852

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.437

High

1326231

PNKD
Probable thioesterase PNKD

1

1

High-throughput

0.437

High

1433711

EMRE
Essential MCU regulator, mitochondrial

1

1

High-throughput

0.437

High

166423

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

104233

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

337825

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

High-throughput

0.407

High

430402

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

683344

TNR5
Tumor necrosis factor receptor superfamily member 5

1

1

High-throughput

0.407

High

914484

EFNB2
Ephrin-B2

1

3

High-throughput

0.407

High

1231145

SCAR3
Scavenger receptor class A member 3

1

2

High-throughput

0.407

High

1288456

SO6A1
Solute carrier organic anion transporter family member 6A1

1

2

High-throughput

0.407

High

1314551

TM192
Transmembrane protein 192

1

1

High-throughput

0.407

High

1380594

IGSF8
Immunoglobulin superfamily member 8

1

1

High-throughput

0.407

High

1446216

SO1B3
Solute carrier organic anion transporter family member 1B3

1

2

High-throughput

0.407

High

328405

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

High-throughput

0.282

High

378879

CD4
T-cell surface glycoprotein CD4

1

0

High-throughput

0.279

Low

279510

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

879499

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1324183

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1333504

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.238

Low

844878

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.232

Low

1334326

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.232

Low

1420730

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025