HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 1210
+	Hs
		337804 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338083 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		337294 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		442833 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		789067 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		383547 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		383673 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		337300 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		442779 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		601837 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		337346 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		789049 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52
+	Hs
		665558 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76
+	Hs
		789068 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23
+	Hs
		337359 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51
+	Hs
		442817 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58
+	Hs
		442812 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Hs
		442789 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL2_HUMAN (707-974): 5.53e-52: 202: 40.37
+	Hs
		789042 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL2_HUMAN (707-974): 5.53e-52: 202: 40.37
+	Mm
		411920 LCK_MOUSE (1-125): 7.28e-41: 143: 19.08		ZAP70_MOUSE (718-961): 2.03e-52: 197: 40.00