HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	16983070
Identification Methods	pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 191
+	Hs
		564442 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		433244 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		433565 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		789092 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		433475 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		789055 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		433314 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		789051 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		433305 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		433322 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		545245 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		433307 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		433239 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		433556 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		789050 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		433217 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		433304 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		433524 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		433671 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		433395 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82