HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: ARHG7 (Q14155)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
Gene: ARHGEF7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.781

Property	Details
Experiments	16983070, 25416956
Identification Methods	pull down, two hybrid, anti tag coimmunoprecipitation, mammalian protein protein interaction trap
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 803
+	Hs
		924563 GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69		ARHG7_HUMAN (1-803): 0: 654: 100.00
+	Hs
		243142 SH21A_HUMAN (1-128): 3.11e-38: 127: 100.00		ARHG6_HUMAN (1-802): 1.77e-161: 489: 51.48
+	Hs
		69770 GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69		B1ALK7_HUMAN (180-797): 8.98e-163: 490: 99.35
+	Hs
		337333 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		VAV_HUMAN (1-778): 3.84e-111: 360: 16.96
+	Hs
		411580 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		VAV_HUMAN (1-778): 3.84e-111: 360: 16.96
+	Hs
		411981 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		VAV_HUMAN (1-778): 3.84e-111: 360: 16.96
+	Hs
		412098 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		VAV2_HUMAN (1-712): 4.73e-111: 360: 17.04
+	Hs
		548677 GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69		VAV_HUMAN (1-778): 3.84e-111: 360: 16.96
+	Hs
		855781 GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69		VAV2_HUMAN (1-712): 4.73e-111: 360: 17.04
+	Mm
		1141129 GRB2_MOUSE (1-123): 1.02e-35: 123: 19.69		VAV2_MOUSE (1-712): 1.26e-107: 351: 16.38
+	Mm
		654982 GRB2_MOUSE (1-123): 1.02e-35: 123: 19.69		VAV_MOUSE (1-754): 3.67e-106: 347: 16.97
+	Hs
		411904 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		FARP1_HUMAN (225-625): 4.7e-96: 324: 21.36
+	Hs
		434097 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		FARP1_HUMAN (225-625): 4.7e-96: 324: 21.36
+	Hs
		279830 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		TRIO_HUMAN (16-803): 4.74e-74: 266: 13.40
+	Hs
		279832 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		TRIO_HUMAN (16-803): 4.74e-74: 266: 13.40
+	Hs
		224698 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		KALRN_HUMAN (34-659): 7.34e-70: 253: 13.25
+	Hs
		224699 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		KALRN_HUMAN (34-659): 7.34e-70: 253: 13.25
+	Hs
		433781 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		ITSN1_HUMAN (21-245): 9.17e-09: 61.3: 14.68
+	Mm
		1159873 SHIP2_MOUSE (3-123): 2.34e-35: 130: 38.84		ITSN1_MOUSE (21-252): 1.33e-10: 67.4: 17.00
+	Hs
		176448 SHIP2_HUMAN (3-122): 1.12e-34: 128: 37.50		ITSN1_HUMAN (21-245): 9.17e-09: 61.3: 14.68