HitPredict

Interactor 1: MGRN1 (O60291)
E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1)
Gene: MGRN1

Interactor 2: UB2G2 (P60604)
Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)
Gene: UBE2G2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 552 Hs			1 165
+	Hs
		244512 MGRN1_HUMAN (1-552): 0: 894: 100.00		UB2D4_HUMAN (4-164): 1.27e-73: 218: 36.03
+	Hs
		244450 MGRN1_HUMAN (1-552): 0: 894: 100.00		UB2D1_HUMAN (4-164): 2.21e-72: 215: 36.03
+	Hs
		244456 MGRN1_HUMAN (1-552): 0: 894: 100.00		UB2D2_HUMAN (4-164): 2.47e-72: 215: 36.03
+	Hs
		244455 MGRN1_HUMAN (1-552): 0: 894: 100.00		UB2D3_HUMAN (4-164): 4.3e-71: 212: 34.78
+	Hs
		952462 RN157_HUMAN (1-495): 0: 654: 58.57		UB2G2_HUMAN (1-165): 5.28e-70: 210: 100.00
+	At
		762748 LUL3_ARATH (25-327): 2.66e-113: 343: 33.76		UBC8_ARATH (4-164): 1.43e-72: 216: 36.03
+	At
		1284382 LUL3_ARATH (25-327): 2.66e-113: 343: 33.76		UBC29_ARATH (4-165): 7.18e-70: 209: 33.33